Well obviously no
one ship will be safe if all the adversary's assets are directed to it. But the PLAN destroyers won't be alone. There will be subs all over the Taiwan strait. Few things are deadlier to the USN than Yuan subs. JH-7A's with antiship missiles. AWACS and J-10/11's. Who knows what else?
With fighters, AWACS, ground based SAMS, and the destroyer's own air defense, it would be a very dangerous mission for a wing of F-18's to attack a PLAN destroyer with harpoons.
I also object to assuming that PLAN's tactics are not good enough to fully exploit the capabilities of its equipment. I also think PLAN has more than a few electronic warfare techniques up its sleeve to counter those the USN. I think it is widely acknowledged that information warfare is one area where the gap between China and the US is quite small.
According to this article, the USN would lose a conflict with PLAN if it sends only 3 CVBG's. (I'll translate it if I have time later.)