Coronavirus 2019-2020 thread (no unsubstantiated rumours!)

Sardaukar20

Captain
Registered Member
Wasn't Moderna supposed to be the most promising?
According to CNN in last Dec:
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Both Pfizer and Moderna are more or less equal in effectiveness. If you can believe the American press. Both are mRNA vaccines. But the biggest difference is storage temperature. Pfizer' vaccine needs - 70degC deep freeze temperatures. While Moderna's vaccine can be stored in a regular freezer.

Moderna had no successful vaccine prior to this. That's why there is suspicions about their vaccines.

Regardless, only time will tell if both Pfizer and Monderna vaccines are effective.
 

hashtagpls

Senior Member
Registered Member
what is the error rate for the mRNA and the lipids, and what is the percentage of mRNA don’t get wrapped in lipids in the production process and ended up in the end products? For the wrongly coded mRNA, what effects do they have?

I’ve pondered this issue before but this is the best I can come up with right now for how cells handle mRNA without stop codons.
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The degradation certainly occurs even in the case of mRNAs during actual infections.

I’m not worrying about degradation. I’m worry about the error in the encoding sequence. Wrong sequence means wrong protein will get produced and may also affect the cell functions

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The mRNA injected has a set sequence so we don’t expect mutations there. Downstream issues would be degradation and ribosomal mistranslation

There’s probably no blanket answers since it would also depend on the specified protein.


I would imagine a profile/study has to be done for everyone of these mRNA platforms in the future just for QC.
What are the chances of these misfolded or "error" proteins becoming prions and giving rise to Creutzfeld-jakob disease "Mad Cow disease in humans" in the future?

What's scary about prions is we won't know until years and even decades into the future when people start exhibiting symptoms.
 
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