Coronavirus 2019-2020 thread (no unsubstantiated rumours!)
- Thread starter localizer
- Start date
Question
mRNA strands wrapped in lipids get inside our cells, trigger mechanisms in the cells to transcribe proteins based on the mRNA strand. If there are errors in the mRNA strand, wrong type of proteins will be produced.
what is the error rate for the mRNA and the lipids, and what is the percentage of mRNA don’t get wrapped in lipids in the production process and ended up in the end products? For the wrongly coded mRNA, what effects do they have?
Can anyone say with 100% certainty those proteins will not fuck up our cells like making them cancerous or worst? Mad cow disease is supposedly caused by proteins.
RNA vaccines use a different approach that takes advantage of the process that cells use to make proteins: cells use DNA as the template to make messenger RNA (mRNA) molecules, which are then translated to build proteins. An RNA vaccine consists of an mRNA strand that codes for a disease-specific antigen. Once the mRNA strand in the vaccine is inside the body’s cells, the cells use the genetic information to produce the antigen. This antigen is then displayed on the cell surface, where it is recognised by the immune system.
mRNA strands wrapped in lipids get inside our cells, trigger mechanisms in the cells to transcribe proteins based on the mRNA strand. If there are errors in the mRNA strand, wrong type of proteins will be produced.
what is the error rate for the mRNA and the lipids, and what is the percentage of mRNA don’t get wrapped in lipids in the production process and ended up in the end products? For the wrongly coded mRNA, what effects do they have?
Can anyone say with 100% certainty those proteins will not fuck up our cells like making them cancerous or worst? Mad cow disease is supposedly caused by proteins.
RNA vaccines use a different approach that takes advantage of the process that cells use to make proteins: cells use DNA as the template to make messenger RNA (mRNA) molecules, which are then translated to build proteins. An RNA vaccine consists of an mRNA strand that codes for a disease-specific antigen. Once the mRNA strand in the vaccine is inside the body’s cells, the cells use the genetic information to produce the antigen. This antigen is then displayed on the cell surface, where it is recognised by the immune system.
Quickie
Colonel
The woman shouting and screaming is amplifying the spreading of the virus 100 times more.
Quickie
Colonel
The W.H.O. should put a new rule. Any new mutations that come out from any country will be the responsibility of that country for preventing its spread to outside of the country.
It's a known fact that the outbreak in New York has come from the European strain of the virus.
LOL... Yeah if it was up to me. I'll be a real embarrassment of a public spokesperson for China. I'll speak to him in plain English. I'll do a Donald Trump. Here is how it'll go:
John Sudworth: Is this China's official position that the virus did not originate from China? Just when the WHO is starting its investigation in China to the origins of Covid-19?
Me: There is evidence that the virus possibly originated in Europe and America earlier than in China. Maybe that's a question to ask to your friends in Europe and in particular America! Don't ask me, ask them! Okay?
John Sudworth: Sir, are you saying that to me? Specifically?
Me: I'm not saying it specifically to anybody. I'm just saying it to anybody who would ask a nasty question like that.
John Sudworth: But that's not a nasty question!
Me: NEXT!!!
John Sudworth: I'm a reporter of the BBC! Do I not deserve an answer to my question?
Me: BBC is fake news. You're fake news. You deserved to be ashamed of yourself. NEXT!!!
CNN reporter raises her hand.
Me: All right, no more questions! We are done for today!
Last edited:
I’ve pondered this issue before but this is the best I can come up with right now for how cells handle mRNA without stop codons.
The degradation certainly occurs even in the case of mRNAs during actual infections.
Last edited:
These three recent spokesperson have all been pretty good. I like Zhao Lijian best for his ability to deliver disdain from his eyes alone and for his dank twitter trolling.
I’m not worrying about degradation. I’m worry about the error in the encoding sequence. Wrong sequence means wrong protein will get produced and may also affect the cell functions
The mRNA injected has a set sequence so we don’t expect mutations there. Downstream issues would be degradation and ribosomal mistranslation
There’s probably no blanket answers since it would also depend on the specified protein.
I would imagine a profile/study has to be done for everyone of these mRNA platforms in the future just for QC.
Last edited: