I don't see why this couple of guys would know what they are talking about. Do you think pilots would know operational economics better than people who actual operate a fleet?
It's a commonly held belief by many around the industry that 2 engines is better than 4. As I said, Leeham news, which imo is the most professional of all aerospace sources, did a real study into it and found that the operating cost (and for airlines, that would include all aspect of engine cost) for 2 vs 4 engine aircraft is about the same. It actually makes no sense why Leap-1A would be harder to maintain than GE9X. Now, in the case of A380, there weren't many of them around, so there weren't many A380 engines compared to 77W engines. Sure, when there are fewer engines around to maintain and fewer fleets operate them, then it's costs go up.
Notice, I didn't mention GTF here. That's a new technology that Pratt spent 30 years and still couldn't get right until many years after service entrance.