Several things about the Kh-31.Syria operates 20 Su-24 bombers, and purchased 78 X-31 anti-ship missiles (I don't know of which version); each aircraft can carry up to three of them. How dangerous this would be to a modern destroyer?
First, it is a decent missile...and dangerous under the right conditions.
As far as this engagement would be concerned, there are three very important advantages that the US forces will have.
1st: The Kh-31 range is less than the range of the Standard Missiles that the AEGIS vessels carry for air defense.
2nd: The US will be providing heavy over-watch via E-3 Sentry aircraft...the US will know if any flight of aircraft are approaching the vessels.
So, based on those first two issues, if the SU-24s or Mig-29s (because they are capable of carrying the Kh-31 too), enter the Standard Missile engagement envelope (presuming other allied aircraft like the French do not intercept them first) they will get shot up badly before they ever launch their missiles.
3rd: In the 1990s the US bought a bunch of MH-31 drones and worked extensively with them to ensure that the AEGIS system could handle the Kh-31. So, if they do get some of them launched, I would expect the combined strength of five AEGIS vessels and their Standard Missiles, ESSMs and finally the CIWS to be very effective against them.
Remember too, the French sent an Horizon DDG to operate with the five US AEGIS destroyers for additional AAW defense. That Horizon is probably going to be effective against these threats as well.
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