Sputnik uses two different Adeno viruses in its two doses
Coronavirus 2019-2020 thread (no unsubstantiated rumours!)
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plawolf
Lieutenant General
No I was just using some back-of-the-envelope math to show how they were manipulating the statistics to show a much higher efficacy rate of the vaccine what than the data actually shows, by using a nonsensical infected number of vaccinated/all vaccinated formula, and showing what that would have looked like had they just applied it to the population.
None of the vaccines is even close to 10% efficiency. All these really high numbers are fake marketing gimmick.
plawolf
Lieutenant General
Basis?
While I’m highly skeptical of the 90%+ figures, I have not seen anything that would put the real efficacy rate at anything close to 10%.
What happens when the virus mutates and we need an updated adenovirus vaccine every two years? I worry the adenovirus vaccines (AstraZeneca, CanSino, Johnson & Johnson, Sputnik V, etc.) will slowly stop working.
My understanding is that adenovirus vaccines rely on the body's immune response to a modified adenovirus. Are we using the same adenovirus vector every two years? Does the body have the same response every time?
I imagine the body's response to the same adenovirus vector would lessen the second, third, fourth time...
We will probably be re-vaccinating ourselves every 1-2 years into the future as certain strains become dominate and then recede. Its not too hard to re-formulate existing vaccines to taret new strains, think of roll-outs between 3-4 months vs the 12 month roll-outs. At some point, we will need to figure out if we can combine the COVID-19 vaccine with the normal flu vaccine (alot of childhood vaccines actually vaccinate for up to 5 diseases at once), so its just part of the regular vaccination schedule for high-risk individuals.
vesicles
Colonel
Our body doesn’t respond to the adenoviral vector. The role of the vector is to carry the COVID viral gene into our cells. These vectors act like shuttles. And shuttles work the same way every time. When the virus mutates enough, we will simply update the SARS-CoV-2 gene portion of the vaccine and mass-produce it again.
No that's not completely true, vector does matter unfortunately and resistance to the host virus also diminishes the effectiveness of recombinant vector virus vaccine based on the host virus.
I saw a paper last year where someone was working on this problem. They suggested an additional modification to Ad5's RNA to make it different enough from wild type to make prior resistance irrelevant. They were calling it a 2nd generation recombinant vector virus vaccine.
Resistance to host virus could also work in your favour - influenza based recombinant vector virus vaccine would actually give you resistance to both the host influenza virus as well as the target virus. China was working on a influenza based recombinant vector virus vaccine for COVID-19, this vaccine could be applied via jet injector and if successful would allow much easier mass vaccination as well as the bonus effect of an additional influenza serotype resistance. Unfortunately I haven't heard much update on this front so it may not have worked out.
