Coronavirus 2019-2020 thread (no unsubstantiated rumours!)

Icmer

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Note that China's rate of third dose/booster vaccination, especially among the elderly, is relatively low.
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The commission said on Monday that 65.7 percent of people aged 80 and above have been fully vaccinated and only 40 percent have received a booster shot.
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In China, over 90 percent of the population have been fully vaccinated. Almost 87 percent of people aged over 60 have been fully vaccinated, but only 66.4 percent of people over the age of 80 have completed a full course of vaccination.
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People aged 60 and above who have received two doses inched up from 85.6% in August to 86.4% in November, while the booster rate rose from 67.8% to 68.2% over the same period, according to official data.
In other East Asian countries, elderly vaccination rates are much higher. For instance, Japan:
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As of March 22, 2022, about 98.3 percent of citizens aged 80 to 89 years in Japan received the second dose of coronavirus disease (COVID-19) vaccinations. The overall share of around 74.8 percent of inhabitants in Japan was vaccinated with the second dose as of the same day.
 

KYli

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Singapore doesn't even have enough population to do an assessment of effectiveness of inactivated vaccines to make a reasonable comparison with mRNA. As everyone knew, Singapore from day one has chosen mRNA over inactivated vaccines and most of its researches are bias.
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Another population-based ecological study in the context of the prevalence of the Omicron variant strain in Hong Kong showed that the third COVID-19 vaccine provided additional protection to adults, especially those over 60 years old and other high-risk groups. After a third dose is administered to people over 60 years old, the protective effect of preventing severe cases is as high as 88 percent and the protective effect of preventing death cases is as high as 93 percent, according to SINOVAC.

A third case-control study among people over 60 years old in Hong Kong showed that SINOVAC's COVID-19 vaccine can effectively protect the elderly from infection and severe diseases during the domination of the BA.2 strain. Three doses of the vaccine can provide 53.9 percent protection against infection, 86.7 percent protection in preventing COVID-19-related hospitalization, 89.8 percent protection in preventing severe COVID-19 complications, and 95.0 percent protection effective in preventing COVID-19-related death in people aged 80 and above.
Note that China's rate of third dose/booster vaccination, especially among the elderly, is relatively low.
How so, China has better vaccination among elderly than most Western nations. Over 92% of Chinese elderly have been vaccinated and over 70% of Chinese elderly have received booster shots which is certainly higher than many countries. MSM is just trying to compare China to Japan and an exceptional few countries that have higher vaccination rate and booster rate.
 

Icmer

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Singapore doesn't even have enough population to do an assessment of effectiveness of inactivated vaccines to make a reasonable comparison with mRNA. As everyone knew, Singapore from day one has chosen mRNA over inactivated vaccines and most of its researches are bias.
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Another population-based ecological study in the context of the prevalence of the Omicron variant strain in Hong Kong showed that the third COVID-19 vaccine provided additional protection to adults, especially those over 60 years old and other high-risk groups. After a third dose is administered to people over 60 years old, the protective effect of preventing severe cases is as high as 88 percent and the protective effect of preventing death cases is as high as 93 percent, according to SINOVAC.

A third case-control study among people over 60 years old in Hong Kong showed that SINOVAC's COVID-19 vaccine can effectively protect the elderly from infection and severe diseases during the domination of the BA.2 strain. Three doses of the vaccine can provide 53.9 percent protection against infection, 86.7 percent protection in preventing COVID-19-related hospitalization, 89.8 percent protection in preventing severe COVID-19 complications, and 95.0 percent protection effective in preventing COVID-19-related death in people aged 80 and above.

How so, China has better vaccination among elderly than most Western nations. Over 92% of Chinese elderly have been vaccinated and over 70% of Chinese elderly have received booster shots which is certainly higher than many countries. MSM is just trying to compare China to Japan and an exceptional few countries that have higher vaccination rate and booster rate.
Compared to Western nations, China has worse elderly vaccination rates. So your assertion is very much false.
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As of December 21, 2022, the percentage of adults 65 years and older who were fully vaccinated against COVID-19 had reached almost 94 percent. This statistic presents the percentage of adults 65 years and older in the United States with at least one dose or were fully vaccinated against COVID-19 as of December 21, 2022.
As predicted you immediately dismissed the study by questioning Singaporean bias even though there was a certainly a large enough population size and no reason to believe the researchers had any bias. Hong Kong data just corroborate Singaporean data - they essentially say the same thing.

I didn't even mention Taiwan, but if you examine their data you will find a higher rate of deaths compared to Japan, South Korea and highly vaccinated Western countries (not including US). That's because their elderly vaccination rate was also relatively low.
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In Taiwan, vaccination rates for people over 75 years of age are the lowest of any age group. As of 7 February, only 69% of people over 75 had received two doses of a vaccine, compared with 88% of people aged between 18 and 29 years.
People extrapolating Taiwan's deaths to China arrived at 840,000. This researcher previously predicted the number of Taiwanese deaths:
He has a good explanation of the Chinese cultural problem with elderly vaccination:
 

Icmer

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People extrapolating Taiwan's deaths to China arrived at 840,000. This researcher previously predicted the number of Taiwanese deaths:
Of course, this is not accounting for ICU capacity, which is worse in China. This study from Fudan University funded by the Ministry of Science and Technology does consider that, and arrived at 1.55 million deaths. One of the researchers even has a competing interest from Sinovac.
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KYli

Brigadier
Compared to Western nations, China has worse elderly vaccination rates. So your assertion is very much false.
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So why don't you post booster rate for Western countries and compare with China. Last time I checked booster rate for 65 over in the US is around 67% and lower if you included 60 to 65.
As predicted you immediately dismissed the study by questioning Singaporean bias even though there was a certainly a large enough population size and no reason to believe the researchers had any bias. Hong Kong data just corroborate Singaporean data - they essentially say the same thing.
Of course it is bias. A few studies that I read from Singapore didn't even bother to breakdown the age of vaccinated population. A few reports even stated that they don't have enough people who vaccinated with inactivated vaccines in certain groups in the disclaimer.

Not really, Hong Kong report has a clear breakdown of 2 doses and 3 doses and age groups and effectiveness of vaccines. Basically after 3 doses, both vaccines don't have much of different in preventing hospitalizations and deaths.
I didn't even mention Taiwan, but if you examine their data you will find a higher rate of deaths compared to Japan, South Korea and highly vaccinated Western countries (not including US). That's because their elderly vaccination rate was also relatively low.
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People extrapolating Taiwan's deaths to China arrived at 840,000. This researcher previously predicted the number of Taiwanese deaths:
He has a good explanation of the Chinese cultural problem with elderly vaccination:
China vaccination rate for 80 or over is 77% not 66%. Your data is outdated. Look, I have strongly advocated for vaccination for elderly. That's the main reason I don't support reopening.

Personally, it is just too early to make any prediction of death tolls. A few months back, I would say over 1 million. However, vaccination rate has greatly improved especially in the last few weeks. It is anyone guess at the moment. There are too many variables that any prediction needs to be constantly updated to be accurate or at least scientifically accurate.
Of course, this is not accounting for ICU capacity, which is worse in China. This study from Fudan University funded by the Ministry of Science and Technology does consider that, and arrived at 1.55 million deaths. One of the researchers even has a competing interest from Sinovac.
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Another outdated assessment. Vaccination rate has increased, ICU capacity has increased, and both are positive for preventing deaths. However, reproduction rate has also been increased which is negative in preventing deaths.
 

MortyandRick

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Note that China's rate of third dose/booster vaccination, especially among the elderly, is relatively low.
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The data are all adjusted for demographic characteristics. No one is still doing double-blind randomized controlled trials because they are impossible to conduct with widely vaccinated/infected populations, so any insistence on it belies an utter lack of familiarity with current scientific data on the pandemic. Next you're going to tell me none of it is reputable because Hong Kongers and Singaporeans are traitors.
I knew you were going to use those studies.
I'm aware of the studies. Inactivate vaccines need a 3rd dose to be more effective than a 2 dose mRNA vaccine but the JAMA article has many limitations, which they even listed.

My comment on the issue of comorbidities were not addressed by you or the study. It is most likely that those with more comorbidities chose the inactivated vaccine due to its longer experience and are afraid of side effects with mRNA. Also you specifically mentioned deaths in your comment which is disingenuous. They never specified deaths. It was mainly severe disease. You can try to extrapolate but you can't make a definitive comment.

Additionally the mRNA vaccine mainly induced immunity to a specific spike protein. Any changes in that protein in a significant way will render the vaccine less useful as opposed to whole virus vaccines. Lastly mRNA is new technology. No one knows what long term effect it may have on a person. If one is elderly it may it matter as much but for those of us who are young, our risk of death from covid is already low, I would definitely prefer inactivated vaccines.
 
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I knew you were going to use those studies.
I'm aware of the studies. Inactivate vaccines need a 3rd dose to be more effective than a 2 dose mRNA vaccine but the JAMA article has many limitations, which they even listed.

My comment on the issue of comorbidities were not addressed by you or the study. It is most likely that those with more comorbidities chose the inactivated vaccine due to its longer experience and are afraid of side effects with mRNA. Also you specifically mentioned deaths in your comment which is disingenuous. They never specified deaths. It was mainly severe disease. You can try to extrapolate but you can't make a definitive comment.

Additionally the mRNA vaccine mainly induced immunity to a specific spike protein. Any changes in that protein in a significant way will render the vaccine less useful as opposed to whole virus vaccines. Lastly mRNA is new technology. No one knows what long term effect it may have on a person. If one is elderly it may it matter as much but for those of us who are young, our risk of death from covid is already low, I would definitely prefer inactivated vaccines.
Plus, I know personal anecdotes aren't really going to fly, but I'll just keep reiterating that it seems my contacts and everybody who has contacts in China report the same thing, in that the infection is spreading fast, but most people get over it in like 3 days to a week. So Sinovac and Sinopharm did prove their worth in the end. Shouldn't be a surprise, Chinese vaccines already proved their worth in Indonesia, Latin America, Pakistan, and the Middle-East.
 

Quickie

Colonel
Hong Kong and Singapore have detailed data on their efficacy against deaths relative to mRNA and they do not show what you are implying.

There are reports of specific prominent people’s deaths in excess of the total mortality figures for the past month. It’s impossible for reasonable people to defend that there have only been around 2 deaths reported in the past 20 days.

I'm just presenting the raw data from the JHU site as it is.

As to why Bangladesh and Cambodia have had so few deaths for the past months (or a year or so?), that will need a lot more scientific investigation to be done, something which we have still yet to see, at least even only for these 2 countries.
 
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Icmer

Junior Member
Registered Member
So why don't you post booster rate for Western countries and compare with China. Last time I checked booster rate for 65 over in the US is around 67% and lower if you included 60 to 65.

China vaccination rate for 80 or over is 77% not 66%. Your data is outdated. Look, I have strongly advocated for vaccination for elderly. That's the main reason I don't support reopening.

Another outdated assessment. Vaccination rate has increased, ICU capacity has increased, and both are positive for preventing deaths. However, reproduction rate has also been increased which is negative in preventing deaths.
I'm not going to do all your homework for you. Vaccination rates, not even including the booster, are consistently higher for elderly in Western countries than in China. You can look at Our World in Data or elsewhere. It's widely available information.

I literally just posted updated Chinese vaccination rates for 80 and over from China Daily/NHC as of December. So it's not outdated data. It moved up to 68% for fully vaccinated, leaving 32% with less than 2 doses. That's not much better.

ICU capacity has only recently increased, which most likely largely reflects the raw number of beds and not the actual HCWs needed. China just hasn't trained as many HCWs as its developed peers, and this time they can't be moved around and allocated according to the location of particular outbreaks. Plus the case fatality ratio for the current variant in China (0.16%, similar to that of influenza) was already reached by non-Covid Zero countries when BA.1 and BA.2 were prevalent. As Hong Kong during its BA.2 wave showed, the intrinsic CFR for immuno-naive (no previous infection or vaccination history) is similar to that of the ancestral strain (in Wuhan).
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We found a generally similar fatality risk for unvaccinated case-patients across age groups in the early period of the fifth wave compared with earlier waves, although the CFR for Omicron cases in person >80 years of age without complete primary vaccination series might be slightly lower than persons infected with ancestral strains. This finding indicates that the intrinsic severity of BA.2 may not be much lower than the ancestral strain.
 

Icmer

Junior Member
Registered Member
I knew you were going to use those studies.
I'm aware of the studies. Inactivate vaccines need a 3rd dose to be more effective than a 2 dose mRNA vaccine but the JAMA article has many limitations, which they even listed.

My comment on the issue of comorbidities were not addressed by you or the study. It is most likely that those with more comorbidities chose the inactivated vaccine due to its longer experience and are afraid of side effects with mRNA. Also you specifically mentioned deaths in your comment which is disingenuous. They never specified deaths. It was mainly severe disease. You can try to extrapolate but you can't make a definitive comment.

Additionally the mRNA vaccine mainly induced immunity to a specific spike protein. Any changes in that protein in a significant way will render the vaccine less useful as opposed to whole virus vaccines. Lastly mRNA is new technology. No one knows what long term effect it may have on a person. If one is elderly it may it matter as much but for those of us who are young, our risk of death from covid is already low, I would definitely prefer inactivated vaccines.

Here's data on mortality. It's consistently lower efficacy for inactivated, which lines up with severity data.
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Vaccine effectiveness (95% CI) against COVID-19-related mortality after two doses of BNT162b2 and CoronaVac were 90.7% (88.6–92.3) and 74.8% (72.5–76.9) in those aged ≥65, 87.6% (81.4–91.8) and 80.7% (72.8–86.3) in those aged 50–64, 86.6% (71.0–93.8) and 82.7% (56.5–93.1) in those aged 18–50. Vaccine effectiveness against severe complications after two doses of BNT162b2 and CoronaVac were 82.1% (74.6–87.3) and 58.9% (50.3–66.1) in those aged ≥65, 83.0% (69.6–90.5) and 67.1% (47.1–79.6) in those aged 50–64, 78.3% (60.8–88.0) and 77.8% (49.6–90.2) in those aged 18–50. Further risk reduction with the third dose was observed especially in those aged ≥65 years, with vaccine effectiveness of 98.0% (96.5–98.9) for BNT162b2 and 95.5% (93.7–96.8) for CoronaVac against mortality, 90.8% (83.4–94.9) and 88.0% (80.8–92.5) against severe complications.

We have neutralization studies (not going to pull all of them up), which show how well vaccines can neutralize variants. They have become an accepted correlate of protection for symptomatic disease (see
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). This researcher
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has conducted many of them with blood from recipients of inactivated vaccines. They don't hold up well against variants. Other researchers haven't found a benefit over mRNA against variants in neutralization either. The T cell/cellular immunity (related to protection against severe disease/death and more durable than B cell/humoral immunity) induced by inactivated vaccines is also not higher than that of mRNA, which again is borne out by real-world data.
 
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