Coronavirus 2019-2020 thread (no unsubstantiated rumours!)

Quickie

Colonel
Something positive about inactivated vaccines like Sinopharm and Sinovac?

Imo, since inactivated vaccines have more antigen sites (of the whole virus) as compared to that of the mRNA spike protein, this could help the vaccine to work across different variants of the virus.

 

measuredingabens

Junior Member
Registered Member
The weakness of inactivated is little or no CD8+ killer T cell response. Same weakness plagues Novavax and Medicago which are protein vax.
It's a weakness shared by the mRNA vaccines as well. Cell mediated responses are somewhat lacking in Covid immunity at least in older individuals when it comes to the vaccines. The current Covid vaccines focus mainly on humoral immunity, so mutations in the spike protein can more easily lead to immune evasion, as seen with the current Omicron variants.
 
Last edited:

Quickie

Colonel
Please, Log in or Register to view URLs content!
This one was published in March this year. In older individuals there is a lower level of cell-mediated immunity.

That is lots of stuff to study through.

In any case "Reduced T Cell and Antibody Responses to Inactivated Coronavirus Vaccine Among Individuals for Above 55 Years Old"
is far from your claim of "The weakness of inactivated is little or no CD8+ killer T cell response."

The other thing is the study is on 2 doses of CoronaVac. The Sinovac/Sinopharm is really a 3-dose vaccine from what we have seen with the Hong Kong University Study. The advantage of the inactivated vaccines in having much more antigen sites (in regard to virus mutation) still holds.

As with any vaccine, one has to weigh the effectiveness against the side effects as well.

Please, Log in or Register to view URLs content!

 
Last edited:

Quickie

Colonel
That is lots of stuff to study through.

In any case "Reduced T Cell and Antibody Responses to Inactivated Coronavirus Vaccine Among Individuals for Above 55 Years Old"
is far from your claim of "The weakness of inactivated is little or no CD8+ killer T cell response."

The other thing is the study is on 2 doses of CoronaVac. The Sinovac/Sinopharm is really a 3-dose vaccine from what we have seen with the Hong Kong University Study. The advantage of the inactivated vaccines in having much more antigen sites (in regard to virus mutation) still holds.

As with any vaccine, one has to weigh the effectiveness against the side effects as well.

Please, Log in or Register to view URLs content!


@measuredingabens
Just to clarify the above response was to WarAndPeace.

I didn't actually see who replied to me.

Sorry for the confusion.
 

tankphobia

Senior Member
Registered Member
Vaccines do not seem like a silver bullet to prevent illness these days either, even the much-vaunted MRNA types, over the last few days me and quite a few colleagues caught the disease after attending a work function together, that is despite all of us being at least triple dosed MRNA, on the bright side the symptoms are flu-like instead of requiring respirators.

At this stage as long as it dramatically lowers death rate it doesn't matter what vaccine the people take, even just one jab can save many lives, it may not stop you from getting sick, but you'll at least live to complain about it.
 

Quickie

Colonel
Please, Log in or Register to view URLs content!
This one was published in March this year. In older individuals there is a lower level of cell-mediated immunity.

Just managed to read the introduction pages of the study.

Looks like this study looks at the Coronavac alone.

It does not make a comparison with other types of vaccines in regard to reduced immunity responses for older age individuals.
 
Top