Coronavirus 2019-2020 thread (no unsubstantiated rumours!)

SteelBird

SteelBird

Colonel
Cambodia reports 5 new case today, the lowest ever since Delta surge; however, 2 new death too, all were unvaccinated.

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SteelBird

SteelBird

Colonel
Quickie said:
All 5 unvaccinated? or 2 dead were unvaccinated? Either way, it's pretty good already.
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For the 5 new cases, 4 were locally transmission, 1 was imported (not mentioned if they were vaccinated or not). The 2 new death were unvaccinated.

Further, Cambodia also announces today to find a second Omicron variant on a Khmer man who has just come back from Kenya. Our efforts to tame the virus will become wasted if the Omicron surge a new wave of infection.
 
Phead128

Phead128

Captain
Staff member
Moderator - World Affairs
jeremyhuex said:
Personally, I don't prefer mRNA. It has very limited antigen scope, low cellular response for preventing severe disease, more expensive to manufacture compared to viral vector, and more rapid decline of antibodies compared to viral vector. Viral vector is the best kind of vaccine IMO if you don't have live virus vaccine. It is as close to live virus vaccine as you can get. Live virus vaccine such as smallpox, polio, measles vaccines is the most effective type of vaccine.
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Rapid decline in antibodies is normal., That's why even inactivated vaccines need booster shots. mRNA and Inactivated both elicits a strong cellular T-cell response, hence high efficacy against hospitalization and death.

I strongly suspect this is an alt account of another formerly banned member. Reported to mods.
 
Phead128

Phead128

Captain
Staff member
Moderator - World Affairs
jeremyhuex said:
Viral vector has much slower decline of antibody compared to mRNA. It is very well explained in this paper:

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As for cellular response, mRNA is only about a tenth as much as viral vector. I quote from the same article:

T-cell responses were assessed by CD4+ and CD8+ intracellular cytokine-staining assays that used pooled S peptides for stimulation (
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). At 8 months, the median CD8+ T-cell responses were 0.016% with the BNT162b2 vaccine, 0.017% with the mRNA-1273 vaccine, and 0.12% with the Ad26.COV2.S vaccine. With all three vaccines, T-cell responses showed broad cross-reactivity against SARS-CoV-2 variants (Fig. S6).
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What is the respective vaccine efficacy against hospitalization and death? They are pretty similar between mRNA and inactivated, and that is what ultimately matters.
 
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