Coronavirus 2019-2020 thread (no unsubstantiated rumours!)

[Phead128]

mRNA lasts much shorter than viral vector. As the paper I posted explains, viral vector is much more stable and has a lot more CD8+ killer T. About 10 times as much. And that was with 1 dose compared to 2 doses of mRNA. So in terms of cost, you are looking at 10 bucks compared to 40 to 60 bucks for Pfizer or Moderna repectively.

mRNA might sound fancy and all that, but in terms of effectiveness and cost it cannot compete with viral vector. Which is one reason it was never used until last year.

If you check out case fatality rate between UK and Germany, it's not surprising UK case fatality rate is a fraction that of Germany. AstraZeneca is the factor.

You aren't answering my question...

Statistically significant differences in T-cell count does not translate into clinically meaningful differences in vaccine effectiveness against hospitalization and death. Real world results matter more than laboratory measurements.

What is observed at the biological level does not necessarily translates into worse protection against hospitalization and death. Both mRNA and inactivated have very similar efficacy against hospitalization and death, regardless of the T-cell count levels observed at the biological level.

 

[Dolcevita]

I think Western media is full of shit.

Is that all that you can say about this?

I think the same can be said about the poster.

 

[Phead128]

Viral vector has much slower decline of antibody compared to mRNA. It is very well explained in this paper:

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As for cellular response, mRNA is only about a tenth as much as viral vector. I quote from the same article:

T-cell responses were assessed by CD4+ and CD8+ intracellular cytokine-staining assays that used pooled S peptides for stimulation (

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). At 8 months, the median CD8+ T-cell responses were 0.016% with the BNT162b2 vaccine, 0.017% with the mRNA-1273 vaccine, and 0.12% with the Ad26.COV2.S vaccine. With all three vaccines, T-cell responses showed broad cross-reactivity against SARS-CoV-2 variants (Fig. S6).

By the way, this is just a correspondence letter, not even a peer-reviewed articles.

Also by the way, that correspondence letter was funded by J&J.

Supported by Janssen Vaccines and Prevention

So please stop citing industry-funded corresponding letters as "evidence" atleast cite peer-reviewed articles.

 

[Phead128]

Duration also matters. If mRNA lasts 2 months, viral vector lasts a year, viral vector would be better despite initial similar T cell response. Do you have a paper that backs up your claim mRNA has similar T cell efficacy as viral vector?

Your J&J-funded correspondence letter is not even a proper peer-reviewed article. And you are demanding evidence? Please share a proper peer-reviewed article that is not funded by J&J.

 

[Phead128]

The funding may have been J&J, the scientists are not. Please be respectful.

J&J-funded "letter to editor" says J&J vaccine is superior in T-cell counts than mRNA vaccines.

Thank you for your biased low-quality evidence.

 

[solarz]

Is that all that you can say about this?

That's all I need to say about it.

 

[Overbom]

Dr. Been explains Omi symptoms seen in UK. Cold symptoms. No fever, no loss of taste or smell, no coughing, no shortness of breath seen in early covid variants. Video dated December 18, 2021.

I would wait until end of December to draw a conclusion. But data from South Africa seem positive on Omicron, less hospitalisations, less deaths

However we should note that South Africa hasany differences from other countries (population with HIV, high infection rates by Delta etc)

 

[SteelBird]

Another two Omicrons are reported on international travelers. So totally four have been found so far. To some of you it might not be anything big deal to discover merely 4 cases of Omicron but to us, we have been trying to hard to contain the virus and we have dropped the daily new cases down to 5. If Omicron breaks in and spread around, all we've done before will be meaningless. SAD!

 

[Tyler]

Does anybody know why India and Japan are currently not affected by the current wave? AFAIK Japan even has tourist in the country again. Is there deliberate undereporting or are they just lucky (for now)?

South Korea for example is highly escalating since they adopted the western method of living with the virus,

In the case of India, it is probably because of both deliberate under-reporting and unintentional under-reporting due to inadequacies of the health care system.

 

[manqiangrexue]

NBC news article about the situation with zhang zhan. It seems that she may not survive prison.

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What do you think of this?

Anyone who breaks Chinese law should be judged by a Chinese judge and sent to jail/punished if found guilty. I trust the judge to do his job and protect Chinese society from criminal activity. No one, especially no foreigner, has any say in this.