as far as engines go, oversized is hardly an aerodynamic detractor as bigger fan means more air sucked in and bigger thrust. one only needs to look at evolution of engines on civilian airliners, those fans just keep getting bigger and bigger in proportion to the fuselage width. and airliners are ALL about aerodynamics and least drag and biggest fuel efficiency.
kawasaki's c-2 transport has pretty large engines for its size, and they're mighty powerful, too. 532 kn of thrust total for a plane with 141 ton mtow. of course, there's the example of c17, with just 720 kn of thrust for mtow of 265 tons. but that's because c17 offers a wide range of capabilities. if one puts a light load on it, it will take off better than a c-2 from unprepared runways. if one loads it up completely, it will be fairly sluggish, but it'll still be loaded with 70 tons, while a c-2 can manage only half of that.