Can’t wait till some unhinged politician puts Apple on the entity list.
News on China's scientific and technological development.
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Can’t wait till some unhinged politician puts Apple on the entity list.
That sounds reasonable. People who emigrate to the US (even just for studies) are probably more liberal and cosmopolitan compared to their peer group on average. I don't think this was true in the 1990s when China had very little to offer in terms of elite science education. Bright Chinese who had the means more or less had to move out.
That's no longer true, as China's university system has now surpassed the US in many key areas (chemistry, physics etc). So the kinds of Chinese students that go today is probably much more self-selected lot in terms of greater openness compared to the 1990s when everyone who could would go.
Even so, the extreme amount of hostility is probably forcing a number of them to simply pack their bags and go back anyway, or accept a substandard career in the US. I personally think this is very stupid move but we live in a Sinophobic zeitgeist, unfortunately. Maddeningly self-defeating.
The Chinese need to form groups among themselves, for the purpose of fighting against Sinophobic attitudes worldwide.
They can learn a thing or two from us here in ASEAN, we survived the pogrom (sorry for being dramatic) and look who control most of their strategic and manufacturing industries.
The key is to assimilate, work hard, be apolitical and a lot of red pockets.
Hesai Technology’s lidar delivery volume exceeded 50,000 units in a single month!
According to news on January 3, 2024, Hesai Technology officially announced that in December 2023, Hesai Technology’s lidar delivery volume successfully exceeded the 50,000 unit mark, becoming the first single-month delivery volume in the global automotive lidar industry to exceed 50,000 units. Taiwan company.
Hesai Technology stated that in 2022, the company's vehicle-mounted lidar will officially start large-scale mass production and will ramp up rapidly in 2023. Currently, with the rapid development of new energy vehicles in intelligent driving, the automotive industry's demand for lidar has also greatly increased. As early as September 2022, Hesai handed over the report card of monthly delivery volume exceeding 10,000 units, successfully launched the first shot of front-mounted mass production, and became the first automotive lidar company in the world to deliver more than 10,000 units in a month. . In December of the same year, Hesai completed the delivery of its 100,000th lidar unit, becoming the global lidar annual mass production champion. One year later, Hesai achieved the achievement of cumulative delivery volume exceeding 300,000 units, once again becoming the first automotive lidar company in the world to achieve this milestone.
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Hesai Technology’s lidar delivery volume exceeded 50,000 units in a single month!
According to news on January 3, 2024, Hesai Technology officially announced that in December 2023, Hesai Technology’s lidar delivery volume successfully exceeded the 50,000 unit mark, becoming the first single-month delivery volume in the global automotive lidar industry to exceed 50,000 units. Taiwan company.
Hesai Technology stated that in 2022, the company's vehicle-mounted lidar will officially start large-scale mass production and will ramp up rapidly in 2023. Currently, with the rapid development of new energy vehicles in intelligent driving, the automotive industry's demand for lidar has also greatly increased. As early as September 2022, Hesai handed over the report card of monthly delivery volume exceeding 10,000 units, successfully launched the first shot of front-mounted mass production, and became the first automotive lidar company in the world to deliver more than 10,000 units in a month. . In December of the same year, Hesai completed the delivery of its 100,000th lidar unit, becoming the global lidar annual mass production champion. One year later, Hesai achieved the achievement of cumulative delivery volume exceeding 300,000 units, once again becoming the first automotive lidar company in the world to achieve this milestone.
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Hesai -- Shanghai, ChinaHesai Technology’s lidar delivery volume exceeded 50,000 units in a single month!
According to news on January 3, 2024, Hesai Technology officially announced that in December 2023, Hesai Technology’s lidar delivery volume successfully exceeded the 50,000 unit mark, becoming the first single-month delivery volume in the global automotive lidar industry to exceed 50,000 units. Taiwan company.
Hesai Technology stated that in 2022, the company's vehicle-mounted lidar will officially start large-scale mass production and will ramp up rapidly in 2023. Currently, with the rapid development of new energy vehicles in intelligent driving, the automotive industry's demand for lidar has also greatly increased. As early as September 2022, Hesai handed over the report card of monthly delivery volume exceeding 10,000 units, successfully launched the first shot of front-mounted mass production, and became the first automotive lidar company in the world to deliver more than 10,000 units in a month. . In December of the same year, Hesai completed the delivery of its 100,000th lidar unit, becoming the global lidar annual mass production champion. One year later, Hesai achieved the achievement of cumulative delivery volume exceeding 300,000 units, once again becoming the first automotive lidar company in the world to achieve this milestone.
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Tianjin Institute of Engineering and Biotechnology: Progress in the development of new generation base editing technology
Recently, Tianjin Institute of Engineering and Biotechnology developed deaminase-independent base editors DAF-CBE and DAF-TBE, and related research results were published in Nature Biotechnology..
Base editing (BE), as a cutting-edge genome editing technology, can achieve precise and efficient single base editing at the genome level. This technology is widely used in fields such as basic research, gene therapy, and cell factory construction. Commonly used DNA base editors are mainly realized by fusing programmable DNA-binding proteins (such as Cas9) with base deaminase, including cytosine base editor (CBE), adenine base editor (ABE) ) and glycosylase base editor (GBE), etc., can realize C-to-T, A-to-G, C-to-G and other types of base editing. However, these base editors target direct editing of C and A bases, and the included deaminase may lead to non-Cas9-dependent off-target DNA or RNA.
A synthetic biology research team led by Bi Changhao, a researcher at the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, and a microbial metabolic engineering research team led by co-researcher Zhang Xueli, developed a deaminase-free (DAF)-independent base editor DAF- CBE and DAF-TBE respectively realize C-to-A and T-to-A base transversion in E. coli and C-to-G and T-to-G base transversion in mammalian cells. Change editor.
This study transformed two mutants of human uracil glycosylase (UNG), UNG (N204D) and UNG (Y147A), through directed evolution, and obtained two highly active DNA glycosylases that can act on CDG4 for cytosine bases and TDG3 for thymine bases. Furthermore, the study fused these two DNA glycosylases with nCas9 (Cas9, D10A) to construct two base editors, CDG4-nCas9 and TDG3-nCas9, for C-to-A and E. coli. Editor of T-to-A. Experimental results showed that the editing efficiencies of CDG4-nCas9 and TDG3-nCas9 in E. coli reached the highest 58.7% and 54.3% respectively. Furthermore, the study targeted the Homo sapiens codon-optimized versions of CDG4-nCas9 and TDG3-nCas9, achieving C-to-G and T-to-G transversion editing in HEK293T cells, with editing efficiencies reaching 38.8% and 48.7% respectively. . The off-target effects of these two editors are lower than those of commonly used cytosine base editors (BE4max) and glycosylase base editors (CGBEs). Therefore, the study named the two editors DAF-CBE and DAF-TBE. In addition, through further engineering transformation, the team optimized the spatial positions of CDG and TDG and obtained new versions of DAF-CBE2 and DAF-TBE2. Their editing window was moved from the 5' end of the original spacer sequence to the middle region, and the editing efficiency of C-to-G and T-to-G was increased by 3.5 times and 1.2 times respectively. DAF-CBE and DAF-TBE achieve efficient editing of human induced pluripotent stem cells (hiPSC).
In summary, after directed evolution, the DAF-CBEs and DAF-TBEs base editors developed by the team achieved efficient base transversion editing in E. coli and mammalian cells without the use of deaminase. Compared with existing prime editing or glycosylase base editors (GBEs), DAF-BEs have comparable editing efficiency, smaller size and lower off-target rate, which expands the base The editing type of base editor provides new technical tools for related research in fields such as industrial strain casting and biomedicine. Recently, relevant research results were published in Nature Biotechnology . The research work is supported by the National Key R&D Program, the National Natural Science Foundation, the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Action Project, the Youth Innovation Promotion Association of the Chinese Academy of Sciences, and the Tianjin Natural Science Foundation..
Recently, Tianjin Institute of Engineering and Biotechnology developed deaminase-independent base editors DAF-CBE and DAF-TBE, and related research results were published in Nature Biotechnology..
Base editing (BE), as a cutting-edge genome editing technology, can achieve precise and efficient single base editing at the genome level. This technology is widely used in fields such as basic research, gene therapy, and cell factory construction. Commonly used DNA base editors are mainly realized by fusing programmable DNA-binding proteins (such as Cas9) with base deaminase, including cytosine base editor (CBE), adenine base editor (ABE) ) and glycosylase base editor (GBE), etc., can realize C-to-T, A-to-G, C-to-G and other types of base editing. However, these base editors target direct editing of C and A bases, and the included deaminase may lead to non-Cas9-dependent off-target DNA or RNA.
A synthetic biology research team led by Bi Changhao, a researcher at the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, and a microbial metabolic engineering research team led by co-researcher Zhang Xueli, developed a deaminase-free (DAF)-independent base editor DAF- CBE and DAF-TBE respectively realize C-to-A and T-to-A base transversion in E. coli and C-to-G and T-to-G base transversion in mammalian cells. Change editor.
This study transformed two mutants of human uracil glycosylase (UNG), UNG (N204D) and UNG (Y147A), through directed evolution, and obtained two highly active DNA glycosylases that can act on CDG4 for cytosine bases and TDG3 for thymine bases. Furthermore, the study fused these two DNA glycosylases with nCas9 (Cas9, D10A) to construct two base editors, CDG4-nCas9 and TDG3-nCas9, for C-to-A and E. coli. Editor of T-to-A. Experimental results showed that the editing efficiencies of CDG4-nCas9 and TDG3-nCas9 in E. coli reached the highest 58.7% and 54.3% respectively. Furthermore, the study targeted the Homo sapiens codon-optimized versions of CDG4-nCas9 and TDG3-nCas9, achieving C-to-G and T-to-G transversion editing in HEK293T cells, with editing efficiencies reaching 38.8% and 48.7% respectively. . The off-target effects of these two editors are lower than those of commonly used cytosine base editors (BE4max) and glycosylase base editors (CGBEs). Therefore, the study named the two editors DAF-CBE and DAF-TBE. In addition, through further engineering transformation, the team optimized the spatial positions of CDG and TDG and obtained new versions of DAF-CBE2 and DAF-TBE2. Their editing window was moved from the 5' end of the original spacer sequence to the middle region, and the editing efficiency of C-to-G and T-to-G was increased by 3.5 times and 1.2 times respectively. DAF-CBE and DAF-TBE achieve efficient editing of human induced pluripotent stem cells (hiPSC).
In summary, after directed evolution, the DAF-CBEs and DAF-TBEs base editors developed by the team achieved efficient base transversion editing in E. coli and mammalian cells without the use of deaminase. Compared with existing prime editing or glycosylase base editors (GBEs), DAF-BEs have comparable editing efficiency, smaller size and lower off-target rate, which expands the base The editing type of base editor provides new technical tools for related research in fields such as industrial strain casting and biomedicine. Recently, relevant research results were published in Nature Biotechnology . The research work is supported by the National Key R&D Program, the National Natural Science Foundation, the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Action Project, the Youth Innovation Promotion Association of the Chinese Academy of Sciences, and the Tianjin Natural Science Foundation..