With America's resources, Spain fought on five fronts and effectively stopped the expansion of the Ottoman Empire. The only reason the Habsburgs did not recreate the Roman Empire was because France and Portugal (also colonial powers) united with Britain, the Ottomans and the Netherlands to avoid it and divided Europe.Byzantium had guns and cannon too. It was not anywhere near a big of a technological change as industrialization where mere decades of differences could separate victory from defeat.
Spain and Holy Roman Empire lost the 30 years war too.
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