Iran could easily blockade the flow of goods into Israel from the Mediterranean side as well now.
The ships don't need to be hijacked, it's enough to hit dozens of them with kamikaze drones,
And the rest of the shipping industry will be fearful to ship there, with increased freight rates, and insurance premiums.
That is already happening now from that direction as well without any major attacks there so far.
This is a very likely scenario, Iranian-backed groups could launch it from Lebanon, Syria, Iraq, whatever, quite easily.
Closing the Red Sea route is only damaging Israel's imports from Asia, which are not much, as they get most of their goods from the Mediterranean.
The Red Sea disturbances are hurting the West in general more than it is hurting Israel, but on the Mediterranean, it would be different.
There are even some rumors that the trade could be disturbed even in Gibraltar thanks to Western Sahara which is pro-Iran, anti-US, and anti-Zionist.
However, the more likely scenario is more missiles and drones near Israel's Mediterranean shores.