Coronavirus 2019-2020 thread (no unsubstantiated rumours!)

vesicles

vesicles

Colonel
An interesting new study. They found that the current SARS-CoV-2 virus can attack white blood cells, especially the T-cells. This is surprising because T-cells have almost no ACE2 receptors. So this means the current SARS-CoV-2 can infect cells with no or low levels of ACE2 receptor. Previous coronaviruses, like SARS-CoV or MERS, cannot infect cells with no/low level of the ACE2 receptor. It has been thought that SARS-CoV-2 should also specifically target cells with high levels of ACE2 receptors. However, this new study suggests otherwise. This may explain why the new virus can infect people so efficiently. And also explain why people with defective immune responses become so critically ill upon infection.

The fortunate part is that, once entering the T-cells, the SARS-CoV-2 virus canNOT replicate anymore. They stay dormant and die with the host T-cells. This is good...

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The new study also tested one of their peptide drugs that has been designed to inhibit viral fusion with host cells. They found some success, which is encouraging...
 
manqiangrexue

manqiangrexue

Brigadier
vesicles said:
An interesting new study. They found that the current SARS-CoV-2 virus can attack white blood cells, especially the T-cells. This is surprising because T-cells have almost no ACE2 receptors. So this means the current SARS-CoV-2 can infect cells with no or low levels of ACE2 receptor. Previous coronaviruses, like SARS-CoV or MERS, cannot infect cells with no/low level of the ACE2 receptor. It has been thought that SARS-CoV-2 should also specifically target cells with high levels of ACE2 receptors. However, this new study suggests otherwise. This may explain why the new virus can infect people so efficiently. And also explain why people with defective immune responses become so critically ill upon infection.

The fortunate part is that, once entering the T-cells, the SARS-CoV-2 virus canNOT replicate anymore. They stay dormant and die with the host T-cells. This is good...

Please, Log in or Register to view URLs content!

The new study also tested one of their peptide drugs that has been designed to inhibit viral fusion with host cells. They found some success, which is encouraging...
Click to expand...
Slight correction: MERS can not only infect T-cells but it can also induce apoptosis. It is unknown at the end of this study if SARS-COV-2 can also induce T-cell apoptosis.
 
Quickie

Quickie

Colonel
manqiangrexue said:
Slight correction: MERS can not only infect T-cells but it can also induce apoptosis. It is unknown at the end of this study if SARS-COV-2 can also induce T-cell apoptosis.
Click to expand...

I recall from one of the you-tube lecture that, one of the symptoms of COVID-9 infection is low white blood cells count.
 
Intrepid

Intrepid

Major
A question that concerns me: does it make a difference whether I only infect myself briefly once or in many cases over a longer period of time?

A short conversation with an infectious person would be an example for once briefly. Maybe not even a directly inhaled droplet infection, but I'm rubbing the virus into my eyes.

An example of multiple and prolonged would be a party night with several party guests who are infectious. There is plenty of dancing, sweating and brotherhood drinking.

I have not been able to find any meaningful studies on this.
 
vesicles

vesicles

Colonel
Intrepid said:
A question that concerns me: does it make a difference whether I only infect myself briefly once or in many cases over a longer period of time?

A short conversation with an infectious person would be an example for once briefly. Maybe not even a directly inhaled droplet infection, but I'm rubbing the virus into my eyes.

An example of multiple and prolonged would be a party night with several party guests who are infectious. There is plenty of dancing, sweating and brotherhood drinking.

I have not been able to find any meaningful studies on this.
Click to expand...

Well, it's all about the viral count. If an infected guy sneezes before leaving the room, you step in the room and into the cloud of his sneeze (it takes a few minutes for the sneeze to clear the air). You are likely toast even without seeing the sick guy. On the other hand, if you have a dinner with an infected guy who sits across the table from you and doesn't do anything weird, you will be most likely fine. Just look at Trump and Pence who had multiple very close contacts with an infected person at a dinner event. And both of them are fine.

With that being said, no contact is the best contact. Don't assume that you will be fine because you are 6 feet apart, or he's not showing any symptoms, or ...... Don't assume anything. Better be safe than sorry. That means no parties. That means minimizing talking with people face-to-face. That means assuming everyone is sick around you. That also means, when you have the urge to visit your family somewhere, assume you are infected too, which means DON'T go! And that means don't rub your eyes. Don't touch your face. You will need some discipline to do these. This may sound a little over the top, but, when I step outside the house, I assume every surface is covered with virus juice and everyone is infected. And I also assume everything coming into the house has also been covered with virus juice.

I've had people talk about not willing to sacrifice their personal freedom because of the outbreak. My response to them: when you are 6 feet under and locked in a box, you won't have any freedom at all. You are fighting the ultimate tyrant who is trying to take away your life, your most fundamental freedom. At this point, the best strategy is to hide from the tyrant. Who would still go out and have fun when they know that someone is out to get them? The virus is out to get us. Better to hide...
 
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Intrepid

Intrepid

Major
I pay attention to the virus clouds. If you felt bad breath or sweat, you were too close. I'm aware. And I always hold my breath or at least breathe through my nose when I walk close to other people.

I am concerned with another question: why do even young people become seriously ill? Is it perhaps because of the intensity with which they were infected by the virus?

Does it make a difference whether I breathe the virus straight into my lungs or my infection starts with a smear infection?

I heard about this in a podcast from a virologist. I would like to know more about it. Was that just a thought that had long since been rejected. Or is this being seriously examined?
 
vesicles

vesicles

Colonel
Intrepid said:
I am concerned with another question: why do even young people become seriously ill? Is it perhaps because of the intensity with which they were infected by the virus?
Click to expand...

Good question! I'm not sure if anyone knows. Even with them seriously sick, very few of them actually dies...

Intrepid said:
Does it make a difference whether I breathe the virus straight into my lungs or my infection starts with a smear infection?
Click to expand...

I still believe its mostly the amount of virus you get. The route of infection is less of an issue, IMHO.
 
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