I see mention of Beta and Delta for the 2nd Gen Sinopharm vaccines
pharmaceutical-technology.com/news/sinopharm-two-drugs-covid/
It is not surprising that Beta and Delta were mentioned because they are the only available variants that any new vaccine can be tested against. It doesn't mean the vaccine is specifically designed against them.
Here is the Chinese source from Sinopharm's head of research institute Li Qiming:
一代设计抗原蛋白时用的是病毒原型株的部分蛋白,如新冠病毒的S蛋白的关键区域。而二代疫苗研发,在抗原的设计上就不一样。
研发团队主要负责人、国药中生生物技术研究院院长李启明进一步解释,针对变异株流行的新趋势,在第一代疫苗的基础上,利用计算结构疫苗学技术平台,通过分子模拟和计算建模方法,对各种变异突变位点的免疫逃逸能力进行了全面的定量计算评估,研发团队设计开发了第二代重组新冠疫苗。
据了解,二代免疫抗原不局限于此前业内聚焦的新冠病毒S蛋白关键区域。也就是说,一代“照猫画虎”越像越好,而二代建模分析、计算评估,有“揣摩神韵”的意思,因此在激发抗体方面,更具“智能”。
Basically, he says that between 1st gen and 2nd gen:
- The design of antigen is different.
- The 2nd gen covers all (many more) possible mutation points.
- Simply put, 1st gen is like copy/pate trying to emulate the virus specific variant as much as possible. The 2nd gen is to model the essence by removing the superficial, more intelligent.
Another Sinopharm source
目前,该新冠疫苗在阿联酋已接种近2000名受试者,初步的研究结果显示,该疫苗安全性和耐受性好,可激发人体产生针对原型株和主要变异株高水平的中和抗体,充分体现了重组蛋白疫苗技术路线在疫苗研发中的优势和特点。
Here it says that the 2nd gen vaccine is
equally effective in generating antibody against the
original and other major variants. This means that they tested on all well known variants and all works the same proving the "broad spectrum"/non variant speciality.
I would make a very rough analog. The 1st gen is like "The animal has black hair, no tail, moving on four legs, it is an ape. But an orangutan is not an ape because the hair is orange." The 2nd gen is like "All animals having no tail and walking on four are apes." I know there are other tailless land animals other than apes, but hope you get the idea.