The Italians make claims that the Oto-Breda 76 mm Compatto has an anti-cruise missile capability, but the USN certainly cannot back that claim with the Compattos in USN service. There are a lot of reasons for this. Number one, that particular gun is thoroughly unreliable. The USN has had to cut back it's rate of fire to keep it together. At the advertised 120 rounds per minute the mount literally shakes itself apart. The US cut the rate of fire back to 90 rpm, but the gun remains unreliable.
Number two, must EU navies cannot afford to expend targets in tests and exercises the way the USN does. They tend to fly their targets at higher altitudes and accept near misses as a "hit" in their scoring criteria, allowing an intact target to be recovered and reused many more times than is typical of USN targets. The USN flies their targets much lower to the water, which is riskier to the target in rough seas, and destroys them with live fire routinely. Average life span for a target in USN service is 3 1/2 operations. USAF targets last twice as many ops, and other Nato navies targets last even longer. Hence, companies like Oto-Breda make exaggerated claims about their guns based on easier tests conducted at the range in Sardinia. The USN cannot duplicate these results at our ranges with our targets, typically Chukars and Firebees flying at two meters above the water and 500 knot speeds. Mirach 100/4 cannot match the low level performance of a Chukar, particulary the low level maneuvers, so the Italian systems are not tested against as high fidelity a target as the USN does.
RAM is much more effective than any existing gun system, but the 21 round launcher is heavier than CIWS, limiting where it can be mounted on ships ( consider that even the light weight AN/SPG-62 illuminator radar is causing cracking problems in the superstructures of Ticonderoga class cruisers ).
Modern guided ammunition is useless against aerial targets. Most is laser guided, homing on the reflected energy of a coded target designation laser and used against land targets. Such rounds remain largelay untested against moving land targets, so to extrapolate such a round could hit a fast moving missile is a stretch. There is a version of JDAM with laser guidance that can hit some slow moving targets. So far, these rounds could not hit a tank moving near it's top speed. Laser homing in a maritime environment is more difficult than over land due to laser backscatter and atmospheric effects from the humid maritime environment.
The other form of guidance is GPS, great against land targets but useless against a moving target.