Well, as many of you have known, Trump's 2018 budget proposal cuts NIH funding by almost 20%. If approved, this will be absolutely disastrous. Thousands of funded projects will be cut. That means potential cures for many diseases will be abandoned.
In desperate attempts to obtain funding, many scientists will have to abandon seemingly crazy ideas and "boring" basic science projects because they won't get funded. However, it is these crazy ideas and boring projects that seem to go nowhere at this moment will later on mature into revolutionary treatment strategies. With such a huge budget cut, these ideas won't get a chance to mature at all. Everyone will have to switch to something safe and something already well established to be funded.
The US is the most advanced nation in the world because it has the most advanced science and technology lead. To maintain such lead, you need to have a continuous evolutionary chain:
(1) every monumental breakthrough starts out as an idea that is seemingly irrelevant to anything in the real world. The idea is sometimes so crazy that even your colleagues will laugh you out of room.
(2) Then as you gather enough evidence to convince a small portion of colleagues, this irrelevant idea evolves into a boring basic science project that only excites the biggest nerds. At this point, the research is only sustained because "it does good science". Another way of saying "I can't find anything wrong in your data". "It makes logical sense, but it still makes no sense...". "what will all this mean even if you get it to work?" "I don't see this going anywhere...". "But I'm giving you the funding out of my shear generosity and because we have enough funding to go around..."
(3) Years and maybe decades later, a breakthrough is made! Colleagues in the field begin to appreciate your work. And they begin to say "wait a minute, there may be something to this idea...". "Maybe we should look at it as well..."
(4) after hundreds and maybe thousands of publications on this idea, people from other fields begin to notice and begin to connect the dots. And people begin to say "wait a minute, this theory may be able to explain this disease and that disease!" All of a sudden, an explosion! My Goodness! He/she has discovered how XYZ (some major diseases) works! Then huge funding flushing into this field. Everyone jumping onto the bandwagon.
(5) Scientists doing translational work and Pharmaceutical companies see the promising future. They begin to develop drugs that are based on this now established theory. Now you begin to see and hear about it in the public. TV shows begin to talk about it. People begin to discuss the possibility of a Nobel Prize.
(6) Drugs based on your now established theory go into clinical trials. And if you are super lucky and hold a patent on one of the drugs, you will get super wealthy...
Absolute every scientific breakthrough must go through these stages. No exception! No matter how big and how small the breakthrough is. As you can see, stages (1), (2) and (3) will only be allow to mature if there's plenty funding. And without (1), (2) and (3), you won't have (4), (5) and (6). This is why only developed nations have advanced science programs because only wealthy nations can afford to invest in enough "irrelevant" and "hopeless" and "crazy" ideas in stages (1), (2) and (3). And when you dump enough money into "useless" ideas, some of them will emerge and become breakthroughs that change the world.
Yes, science is a luxury only for spoiled people who have enough money to throw around. You certainly can't afford to think about science when you have to worry about putting food on the table tonight. However, if you look back at history at any point, advanced science is always what provides a civilization the means to gain and maintain superiority and supremacy.
My question is: is the US satisfied with being a mediocre country that has enough to feed its people, or does the US want to stay as the supreme leader in the world? If the answer is the latter, the only way to do that is through science and technology. Why? Because science is a luxury that only wealthy nations can afford. That makes science one of the few advantages only available to wealthy nations. Abandon it, you abandon your advantage and you abandon your place in the world.