Real life thread

B.I.B.

Captain
At yesterday's seminar by the Nobel Laurate, he told a few funny stories about what they did "back in the days".

1) he said "well, when we were still allowed to do this... We gathered a whole bunch of medical school students and graduate students and fed them half dozen eggs, half pound of bacon and a big tall glass of milk shake (also containing two raw eggs). Then we drew blood every hour to monitor their cholesterol level in their blood. To our surprise, their plasma cholesterol level did not go up at all. That is why nowadays you can go and get your blood cholesterol level checked without fasting because our body maintains cholesterol level in blood very well. Well, we can no longer do this kind of experiments, obviously..."

2) At the end of the talk, he said this: "in one of the clinical trials that we did in the 80's, we collected hundreds of people with blood cholesterol level as high as 300 and conducted experiments. Of course, we put half of them on placebo... If we do this today, we would be arrested and executed... Can you imagine giving people with dangerously high blood cholesterol levels only placebo and no actual treatment and 'lie' to them about it?"

We had a similar incident in relation to women who had cancer of their reproductive systems. When the story broke decades after the period it occurred, a few people who had an illustrious career in the field of teaching and research in medicine, had their names tarnished forever. But how can one conduct these experiments without control groups?
 

vesicles

Colonel
We had a similar incident in relation to women who had cancer of their reproductive systems. When the story broke decades after the period it occurred, a few people who had an illustrious career in the field of teaching and research in medicine, had their names tarnished forever. But how can one conduct these experiments without control groups?

Exactly... You will need controls to do a proper double-blind test... It is indeed a moral dilemma, a big one. We need to do these expts to learn how diseases work so that we can save lives, but how to protect those involved in the test??? Volunteering is the only option. Tell the volunteers that once the test begins, there is a possibility that they could be put into a placebo group. No one will know since these groups would be randomly chosen and neither the doctors nor patients would know which group it is.

Doing experiments using human subjects is always nerve-wrecking. Tons of paperwork to do and endless regulations to follow. That is why I try my best to stay away from clinical stuff.

Even doing experiments with animals is a huge hassle nowadays. Again, tons of paperwork to do and endless regulations to follow. But, I guess it is all to protect the animals. Before each lab establishes animal protocol, we all have to go through animal training. One of the lessons is to watch a video, which contains plenty footage of how lab animals used to be treated "back in the day". Man oh man! some of the footage is more horrifying than the most gruesome horror movies you can think of. The first time I watched the video back in grad school, I felt nauseated and didn't eat anything that day...

I did my first postdoc in a gastroenterology lab. So I had to get familiar with all the classic experiments in the field. Back in the 70's when people tried to study stomach barrier functions, they used dogs. In order to better control contents they added to the dog stomach, they would do a simply surgery to the dogs: opening up the belly and take out the stomach. Note, I am NOT talking about completely removing the stomach, but simply placing the stomach on the outside of the dogs' bodies. Then valves would then be added. Dogs were well alive and could eat and drink "normally" with their stomach hanging outside of their bodies. They would let the dogs acclimate for 3 days before doing experiments to measure stomach barrier function and ulcer formation, etc.
 

Air Force Brat

Brigadier
Super Moderator
Exactly... You will need controls to do a proper double-blind test... It is indeed a moral dilemma, a big one. We need to do these expts to learn how diseases work so that we can save lives, but how to protect those involved in the test??? Volunteering is the only option. Tell the volunteers that once the test begins, there is a possibility that they could be put into a placebo group. No one will know since these groups would be randomly chosen and neither the doctors nor patients would know which group it is.

Doing experiments using human subjects is always nerve-wrecking. Tons of paperwork to do and endless regulations to follow. That is why I try my best to stay away from clinical stuff.

Even doing experiments with animals is a huge hassle nowadays. Again, tons of paperwork to do and endless regulations to follow. But, I guess it is all to protect the animals. Before each lab establishes animal protocol, we all have to go through animal training. One of the lessons is to watch a video, which contains plenty footage of how lab animals used to be treated "back in the day". Man oh man! some of the footage is more horrifying than the most gruesome horror movies you can think of. The first time I watched the video back in grad school, I felt nauseated and didn't eat anything that day...

I did my first postdoc in a gastroenterology lab. So I had to get familiar with all the classic experiments in the field. Back in the 70's when people tried to study stomach barrier functions, they used dogs. In order to better control contents they added to the dog stomach, they would do a simply surgery to the dogs: opening up the belly and take out the stomach. Note, I am NOT talking about completely removing the stomach, but simply placing the stomach on the outside of the dogs' bodies. Then valves would then be added. Dogs were well alive and could eat and drink "normally" with their stomach hanging outside of their bodies. They would let the dogs acclimate for 3 days before doing experiments to measure stomach barrier function and ulcer formation, etc.

Wow, and I am gonna post a food drooler for you Texas boys that like Pinto Beans, I put my pinto beans in the crock pot last night about 10:30 pm, cooked them about 4 hours on high, got up and threw 4 strips of bacon in and some salt and garlic powder, turned them down to low, I got called in to sub in Jr. High Science-topic was weather and low pressure, and genetics in the eighth grade, my beans cooked all day, had a bowl before play practice at church, then came home and fixed my Tex/Mex refried beans,

sautéed onions and garlic, little cummen, chili pepper, and paprika, with two cups of pintos, stirred together and mashed the beans, served hot with sour cream, and grated cheddar and Monterey Jack, white tortilla chips to dip with, wifey loved it, she ate more than she wanted, she is too skinny though, so no harm no foul, but they were good and one of the twins loved it too. Wish you boys were here to share it with me!
 

Jeff Head

General
Registered Member
taken out my door five minutes ago.


2013-1206-WeatherPM.jpg


Our radar map three minutes ago.
 

Jeff Head

General
Registered Member
The results of last night's radar image in our valley in SW, Idaho. In the nearby mountains there are now feet of snow..


[video=youtube;VFJoFejny54]http://www.youtube.com/watch?v=VFJoFejny54[/video]
 

bd popeye

The Last Jedi
VIP Professional
The present temperature in Cedar Rapids is a balmy 11F(-12C)..

Dang,... it's so cold outside I just saw a deer fart a snowflake!:eek:
 

Jeff Head

General
Registered Member
The present temperature in Cedar Rapids is a balmy 11F(-12C)..

Dang,... it's so cold outside I just saw a deer fart a snowflake!:eek:
We are at 2 F here right now, probably going to be -5 F before morning.

Here, it is so cold, that when any animal or human farts outdoors, you cannot even hear or smell it until it thaws out! LOL!
 
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