The B-21 as an interceptor is simple. Have a giant high-powered AESA. Install heavy interceptor missiles, perhaps hypersonic. Presto, you're shooting down enemy non-stealth bombers at 800 km.
What you are talking about is not an interceptor it's the "missile truck" concept and often was proposed to partner with fighters like the F35 and F22 to use their secure data links and radar. The first proposed version was based of B1 The current is F15X. Either way it's not likely relivent to B21. This by the way can also be said of trying to add such to any flying wing stealth bomber.
First although the DAS system is stated as being able to track ICBM launched from extreme ranges. ICBM are Large rockets. They burn a lot hotter than fighters and a lot higher where the high IR can stand out more.
There is still no proof that EO can replace radar in fighters. As to LPIR. These are continually upgraded especially now it's easier as the hardware changes less and modifications are more software based.
The idea is and was to use a large payload missile platform to make the kills. It would work like the reverse of a Awacs in a manor more like a fix hunt. The LO fighters (Hounds)find the targets the big aircraft (hunter) kills them.
Using the datalink and hounds means that even if the enemy got a track on one LPIR, they wouldn't nessisarily save themselves as the kill can still come from others.
Second numbers. Most put B21 at a 100 units some push for 150. I am bold and say 200-300 those numbers are probably a little high for H20 but, no matter the number you use you have to consider that it is meant to replace B1,B2and B52 (H6 for the PRC) and maybe grow the bomber force some more.
The special missions eat into those numbers.
The USAF has a stated want to a LO tanker. So adding a tanker version is logical the size of the aircraft comes in to boot as they need a substantial bird to tank. So either a totally new program for a stealthy transport (still an option that has been a want of SOCOM since the 80s) or Buy additional Bomber frames and convert. It's logical to partner LO fighters and other birds with an LO flying gas station.
Either way this is bare minimum in the dozens perhaps hundred+ that means that 100 is used up. Hence higher numbers 100 bombers +50 (the minimum i feel ) tankers eats the interceptor out of house and home.
They have wanted ISR as well but if its aim is to replace E8 thats a specialized mission and only really needs a dozen or so. although personally I think a drone is the better option for this and AEW. As smaller cheaper drones can be more in number and spread the picture.
So 100 B, 50+ KB, and 20 EB. That puts it in the 150-200 units. easily. Or you break it off and use UCAV based drones cheaper and more numerous. Because of the threats in EW more and more voice coms are restricted so no need to have a controller.
add in a Tac Air mission and it eats up the airframes. Because you are going to need easily dozens if not more. You would need a full 300+ good luck getting that approved. Unless you basically kill any other programs.
For the PRC though it might not be out of the question for a missle truck if the DIA report is accurate then the faster regional fits the bill of the original missile truck