Yeah, because of the complexity of the system, biology needs more rigorous experimental design, including statistical analysis and control. Even with statistics and control, we don't have a clue what's going on 50% of the time. even when we have some clue, it's more like blinds feeling an elephant, which demonstrates how long we have to go to understand biology...
BTW, what do you think about PLoS One? I have one publication in PLoS One. Even though it finally got an impact factor, which, at ~4.7, is not so bad, I still feel a little weird about it...
---------- Post added at 08:07 AM ---------- Previous post was at 07:59 AM ----------
WOW! Your example might be an isolated case? Although I have never walked into a Chinese lab before, both of my parents are scientists and have worked in China many years. My dad is an inorganic chemist and my mom is a nuclear chemist. from what I can tell from their photos in the lab, they had well-organized labs. Of course, the level of the research was also different. My parents worked at Institute 401 (formerly 601) in Beijing, which is still the pinnacle of China's nuclear research.
---------- Post added at 08:15 AM ---------- Previous post was at 08:07 AM ----------
Well, everyone likes positive results. Who doesn't want to be proven right? The difference is, I think, we have been trained NOT to ignore the negative. Since the first day in graduate school, my adviser has drilled into me that negative data can lead to surprises, which might lead to amazing discoveries. I think one thing to be sure is that most of the CHinese scientists are more short-sighted and they only look at the immediate results that can prove their hypothesis correct. Of course, that ties with how well they can get funding in the future. If they show their original hypothesis is wrong, that might affect their credibility and their ability to get funding. Of course, this also reflects their insecurity. People here in the State love to be proven wrong. That means your understanding of the matter has elevated to a new level. I guess it all depends on how you look at things.
I think this also leads back to my initial point. Chinese simply don't have the patience to do deeper science. In order to develop a good theory, one has to propose hypothesis and design experiments to test it. Most of the time, you'll get negative data suggesting your hypothesis is wrong. You just have to keep modifying the hypothesis until it gets right. Sometimes, this process might take months, if you are lucky. Most of the time, it might take years or even decades. You need to be patient and have the dedication and resilience.
I'm going through this exact process as we speak with one of my projects. We saw this interesting phenomenon and are trying to find the molecular mechanism for it. We can see the light at the end of the tunnel because this potential mechanism could explain how a protein that is critical in cancer development is activated. However, no matter what we try, it gives us negative data. It's frustrating, to be honest. It's like you can see the treasure sitting there on the other side of a river. You just can't seem to find a bridge/boat to get to the other side. The treasure just sits there and taunts you. But, we now know what mechanism is NOT a factor in activating this protein...
---------- Post added at 09:29 AM ---------- Previous post was at 08:15 AM ----------
I used to work in an organic chemistry lab as an undergrad. I have to say that organic chemistry is the messiest science field ever. No one cares how much of the stuff you are adding. I still remember, on my first day in the lab, my adviser simply pour half a bucket of some chemical into the flask and spill chemical powder everywhere on the bench. I was shocked, to say the least. I was sophomore at the time and was taking organic chemistry class. In the lab section, we had been shown how to carefully measure everything. And yet, this expert in the field was simply pouring stuff out... And this was not a Chinese lab at all. in fact, I was the only Asian in the lab.