Coronavirus 2019-2020 thread (no unsubstantiated rumours!)
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vesicles
Colonel
I don't agree with that. In my opinion, corners have been cut for sure. A lot of vaccine development is to validate long-term side effects, especially for new techs like mRNA vaccines. These long-term evaluations may take years to finish since the goals will be to see how these mRNA vaccines may affect the long-term health of subjects. No amount of bureaucracy can affect this. You can't create any condition in your trials to speed up these time-dependent factors. You must spend the actual time to evaluate these things. If you are pushing out a vaccine in less than a year, I am 100% sure that these long-term considerations have been pushed aside. And this is true for ALL COVID-19 vaccines currently on the market or in the pipeline.
With that being said, with the horrific situation all around the world, a vaccine is better than any other strategies that I myself can think of. Even China's current strategy only works in the short-term, but is not sustainable. No country can afford to lock its border and its domestic society too long. Such high-pressure and high-intensity environment are simply not sustainable for the people and the government. Vaccines are the only solution. It's like in a desert, we are in serious shortage of water. And you spot a little pond. Yes, you worry about the cleanliness of water in there. Some bacteria in there might cause long-term issues with your liver and kidney, etc. But you need to survive the next couple days to allow you to walk out of the desert before worrying about what happens 20 years down the line.
This is why I have decided to take the shot myself. I usually consider myself very disciplined. I have been trained by the best in the world in various ways to prevent contamination of all kinds of little critters. And I have been practicing these methods in the lab on a daily basis, thus very accustomed to these tedious practices. Additionally, both my wife and I have been the biggest couch potatoes that we know of. We don't go out often even during normal times. Our ideal weekend would be a couple days without ever having to leave home, not even turning off our house alarm. To simply put, we are the most adapted to the current pandemic life style. Yet, we have been mentally and physically exhausted. I've had it enough. I want this to end, NOW!
If you guys remember, I was on the fence about the vaccines a few months ago. I was swung completely to the side of the vaccination after reviewing the published data. I think they've exaggerated their efficacy at the beginning. Even with the shortcomings, the vaccines are still considered as highly effective. Their side effects are tolerable and considered as normal for any vaccines. This is why I am very happy to get the vaccine. I can't wait to get my second shot in a few weeks.
This is a damn godawful result. This is barely over the WHO limit by 0.4%. And no, they did not include asymptomatic cases.
They also did not say how many suspected Covid cases that did not come up on the PCR test there were.
They need to publish the data so we have the exact information.
At the end of the day it is what it is. It passed the 50% hurdle. And it's very effective against the need for hospitalization. So by all means use it. But China is way behind on the pharmaceutical sciences.
As a medical technology, mRNA vaccines seem safer than an adenovirus vector. There's no reverse transcription mechanism in human cells, so there's no way for that material to get permanently written into the genome. Eventually the mRNA just degrades, while the whole point of an adenovirus vector is to add new DNA into cells.
vesicles
Colonel
Yes, that's what we expect based on our understanding of biology of mRNA. However, like I've said before, never assume anything when it comes to biology/medicine without actual experiments.
manqiangrexue
Brigadier
That is damn godawful reading comprehension. The last sentence:
"Ricardo Palacios, medical director for clinical research at the Butantan biomedical center in Sao Paulo, said the new figure included infections that were so mild or asymptomatic that they did not need clinical care."
Go hound your western handlers for their data. China's busy vaccinating itself and its partners.
Hmmmm, seems to contradict that it's "damn godawful" if it'll not only save your life but prevent you from any serious effects. That's the important part that you begrudgingly admit.
By some random amorphous definition that puts China "way" behind at basically everything including "pandemic readiness" and "national stability" LOL Until shit hits the fan and we see that China's actually way ahead.
Another article about the chinese results: (just use incognito if your limit is up for the month)
However, this is intresting:
"Phase 3 trial data for the US-based Pfizer-BioNTech Covid-19 vaccine, for example, gives a 95 per cent efficacy rate. However, out of the 44,000 volunteers there were 3,410 participants who displayed Covid-19 symptoms but were not tested, according to a US Food and Drug Administration report. In the unlikely event that all these participants tested positive, the total efficacy rate would drop to below 30 per cent."
However, this is intresting:
"Phase 3 trial data for the US-based Pfizer-BioNTech Covid-19 vaccine, for example, gives a 95 per cent efficacy rate. However, out of the 44,000 volunteers there were 3,410 participants who displayed Covid-19 symptoms but were not tested, according to a US Food and Drug Administration report. In the unlikely event that all these participants tested positive, the total efficacy rate would drop to below 30 per cent."
You didn't watch the press conference. The criteria for infection is below:
They must have one of a list of symptoms and then they are tested to detect SARS-Cov-2 nucleic acid sample. No symptoms, no test, no infection.
manqiangrexue
Brigadier
You cited the article for your argument, and when proven wrong then make opposite claims based off of Twitter? LOLOL Like I said, damn godawful reading comprehension.
Also, your Twitter says that exhibiting symptoms is cause for immediate testing. Where does it say that those who fail to exhibit symptoms are automatically assumed negative and not tested even at the end? Cite it, because it's a long thread and I'm not going to comb through it, especially since the medical director in the article says that asymptomatic cases were counted.
But hey, even asymptomatic cases were not counted, that's still wayyy better than what the US does. Take all the guys who do have COVID symptoms and refuse to test them, call them negative, say you got 95% LOLOL The things that the US will do out of desperation to compete with China...
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