Depends on what you are hitting. MIRVs were such a big thing in the cold war because they allowed the attacker to target multiple counterforce targets (bomber bases, silos, SSBNs in piers, depots, etc...) with a single missile. This was a huge thing in the era when early warning and C3 weren't very reliable. It meant most of your nuclear arsenal could be destroyed by a small fraction of adversary missiles.
If you are blowing up cities MIRVs don't matter much. Because of geometric and MIRV-bus-related constraints, you get more yield per unit of payload weight as you decrease the number of warheads your missile carries.
Let's imagine a DF-41 with 10 150 kt warheads, which is realistic according to what we know. With decoys, the MIRV bus and re-entry vehicles, the total payload would be around 1800 kg. It is quite realistic to get 7 MT from a 1800 kg single warhead payload.
View attachment 108943
You can see this relationship in the R-36M2 missile too. It can carry 10 1 MT warheads to an 11000 km distance or it can carry a single 20 MT warhead to a 16000 km distance.
So there isn't much gain in increasing the number of warheads if you don't pursue counterforce.