Ask anything Thread
- Thread starter Jeff Head
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As long as you are able to maintain your medical certificate, and pass your biennial flight review, you are legal. Certain very light aircraft are flown on an LSA, wherein your drivers license serves as your medical, and gliders and certain ultra-lights are self certified.
all the pilots were experienced according to initial reports, the area off the harbor is a non congested area where lots of air-work is done, and that may have caused the conflict.
there has always been a lot of general aviation activity in Sunny California.
Is there any thread for servicemen to post their stories? Cant find it eccept popeyes.
vesicles
Colonel
Thank you, a1a2a3a4a5a6a, for post this article. It is fascinating. The findings in this study definitely challenge the existing dogma of modern genetics. It is especially intriguing that they found a lower mutation rate for highly expressed genes. This makes sense because these genes must be more critical to the survival of the species, thus need to be protected from random mutations. Let's keep an eye on this group and see what they find next.
This, however, does not change the fact that, in order for any mutant to become dominant, the dominating species must extinct. This is still the foundation of evolution. No livin things can slowly mutate to gain or lose certain physiological features.
Thanks for your reply. For example, the confidence level of randomness in quantum fluctuations is beyond 5 SD, as inferred from numerous measurements verifying the Standard Model in particle physics. I am just wondering how bullet-proof the concept of randomness is, as applied to mutations and evolution, when the physical origins of this approximation seem to be unspecified and almost taken as default. Are the underlying mechanics, adiabatic, entropic, quantum,....... and thoroughly verified?
Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer
Pedro M. Enriquez-Navas1, Yoonseok Kam1, Tuhin Das1, Sabrina Hassan1, Ariosto Silva1, Parastou Foroutan1,*, Epifanio Ruiz1, Gary Martinez1,2, Susan Minton3, Robert J. Gillies1,4 and Robert A. Gatenby
Science Translational Medicine 24 Feb 2016: Vol. 8, Issue 327, pp. 327ra24
DOI: 10.1126/scitranslmed.aad7842
"Conventional cancer treatment strategies assume that maximum patient benefit is achieved through maximum killing of tumor cells. However, by eliminating the therapy-sensitive population, this strategy accelerates emergence of resistant clones that proliferate unopposed by competitors—an evolutionary phenomenon termed “competitive release.” We present an evolution-guided treatment strategy designed to maintain a stable population of chemosensitive cells that limit proliferation of resistant clones by exploiting the fitness cost of the resistant phenotype"
A group at Tampa FL, is also invoking evolution for cancer treatment.
Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer
Pedro M. Enriquez-Navas1, Yoonseok Kam1, Tuhin Das1, Sabrina Hassan1, Ariosto Silva1, Parastou Foroutan1,*, Epifanio Ruiz1, Gary Martinez1,2, Susan Minton3, Robert J. Gillies1,4 and Robert A. Gatenby
Science Translational Medicine 24 Feb 2016: Vol. 8, Issue 327, pp. 327ra24
DOI: 10.1126/scitranslmed.aad7842
"Conventional cancer treatment strategies assume that maximum patient benefit is achieved through maximum killing of tumor cells. However, by eliminating the therapy-sensitive population, this strategy accelerates emergence of resistant clones that proliferate unopposed by competitors—an evolutionary phenomenon termed “competitive release.” We present an evolution-guided treatment strategy designed to maintain a stable population of chemosensitive cells that limit proliferation of resistant clones by exploiting the fitness cost of the resistant phenotype"
Hello,
I am new here so don't know the ins and outs of this forum. However, I did notice in the rules, it said:
Are there any specific "off topic" forums on here? Is the only off topic ares the "Members Club Room"? Or are there any other off-topic places?
Don't worry, I'm not going to spam the place, I was just wondering where everything was here.
Thanks!
I am new here so don't know the ins and outs of this forum. However, I did notice in the rules, it said:
Are there any specific "off topic" forums on here? Is the only off topic ares the "Members Club Room"? Or are there any other off-topic places?
Don't worry, I'm not going to spam the place, I was just wondering where everything was here.
Thanks!
vesicles
Colonel
This is a very interesting study. Treatment resistance has been one of the biggest hurdles in cancer treatments. Many patients develop resistance to treatment, indeed a classic case of tumor cells evolving to develop resistance. By maintaining the dominating treatment-sensitive tumor cells, this strategy effectively keeps resistant cells at bay using the dominating tumor cells to kill off resistant cell. Brilliant! A nice use and demonstration of evolution theories. Nice find!
I am anxious and excited to see how they progress. I hope they can move into clinical trial soon. This is not a new drug, but a new treatment strategy using existing drugs. So it should be much easier to begin clinical trials.
Yep, similar to your earlier suggestion in another thread, of using less antibiotics and preserving some of the responsive germs, which would in turn compete with the resistive germs and avoid an eventual breakout.
Some are concerned that it may take effort to pursuade the oncologists in changing their established practice of aggressively trying to kill all cancerous cells, which would leave the resistive cells uncontested.
By the way, IMHO, environmental selection can steer the initial distribution into certain outcomes, such that mutation may not even need to be strictly random for evolution to work. Similar to a system of partial differential equations with attractors.
Some are concerned that it may take effort to pursuade the oncologists in changing their established practice of aggressively trying to kill all cancerous cells, which would leave the resistive cells uncontested.
By the way, IMHO, environmental selection can steer the initial distribution into certain outcomes, such that mutation may not even need to be strictly random for evolution to work. Similar to a system of partial differential equations with attractors.