No, the majority of drone assembly facilities would likely never be wiped out. Especially if concealed, dispersed and protected adequately by being placed underground and in other well-protected structures, such as mountains or reinforced bunkers. Drones are also far more than simply "guided munitions". They allow a defending nation to accurately destroy invading forces from great distances by spamming the battlefield, chasing down soldiers and equipment on the move, and maneuvering around obstacles, barriers and shelters used by the invaders to protect their assets. Their cheapness and simplicity to construct is also another major benefit compared to other forms of guided munitions. There is simply no comparison.
That's not to say that other forms of munitions will be of no use. Iran has plenty of artillery, ATGMs and mines to make sure that America suffers casualties at every turn, and from every kind of munition possible.
Both Japan and Germany were fighting two large, countries at once. Both had enemies on both sides that were far more populated, and in Germany's case, far more industrial. In regards to industry, Iran's current steel production, which is a good metric of industrial capacity, is only half that of America's. The US' steel production was many multiples that of Japan's during WW2. And as I said, the differences in topography and land size will make this nearly impossible.
The U.S. could mobilize ten times over if they would like to. It would still make little difference.
You just described drones as cheap but maneuverable guided munitions, which is what I already stated. Issue on that front is however that the US posesses better real-time intelligence gathering and the means to dismember workshops that provide on an industrial scale (and thus have the associated dimensional and logistical footprint). In an all out war scenario the cost of bombing these targets several times over would be seen as worthwhile.
Steel production isn't a particularly good metric of industrial output when the produced steel cannot be sufficiently converted into critical warfighting equipment. Especially nowadays, as the resources necessary for warfighting have tremendously diversified. Again, you're comparing a heavily constrained regional power with two large powers of their era. Iran is, in regional context one of the larger players, but in a historical or even contemporary global context, they're barely a middle power and that's worth keeping in mind.
The only reason Americans are struggling to sufficiently crush Iranian forces is because they're risk averse (already talked about at length). Relying on low volume, tactically low impact, long range munitions and missiles. 3-6 F-15s lost is already making them shudder and even more cautious. For Russia the 20th lost Su-34 is nothing of value because they produced 25 in the meantime. If the Americans were not so sensitive to losses and concerned with projecting a certain image of their forces. I.e if they were willing to lose dozens of fixed wing aircraft in order to achiev tactically useful results quickly, they would have an easier time depleting Iranian offensive capabilities.
Two sides who play a game of "don't touch me, I don't touch you". One too scared to commit in the appropriate intensity due to fears of domestic reactions, the other too occupied with striking Gulf state pleasure resorts rather than hammering Israeli assets into the earth indiscriminately. While Israel is Israel and only concerned about killing as many civilians as possible anywhere they go.
The current trajectory is the culmination of American cuckoldry and zero pain tolerance, Iranian dispersed organization but lacking coherent goals beyond survival and the Israeli desire to wipe out all people in the region that don't roll over and let them walk all over them.
If any of these circumstances were different, if the Americans were willing to take losses and risks, if Iranian forces would pursue tactical goals or if Israel wasn't genocidal, then the situation would be very different.