Meshud's biggest asset was that he could hold the various tribes and factions that make up the movement together. Without that the movement will start fracturing until there is a new leader. The US and Pakistan have to take advantage of the momentary disorder and split the Taliban. Hopefully some leaders will be more willing to switch sides than lose the struggle for leadership (especially likely given the tendency of people in that part of the world to switch sides in war, and the fact that that the losers in this struggle will probably die). This situation might pan out like that in Iraq, where the death of Abu Musab Zarqawi and other leaders caused disarray and in Al Qaeda in Iraq, giving the Sunni tribes motivation and room to switch sides.