Gangsters and hoodrats don't hesitate when it comes to shooting a cop and many see it as an honorable achievement. This isn't much different. US has a massive gang population. ICE nazis will create an impetus to develop armed resistance.
Armed civilian vs police state combat will only ever go one way. It’s just suicide with more steps since ICE has functionally unlimited reinforcements as well as the ability to call in literal military armoured vehicles. If they need to, they can also call out the National Guard with tanks and artillery. The police state has total escalation dominance and will steamroll open armed resistance at any scale.
Even the Americans themselves only managed to overthrow British rule because of massive French financial and material support. Basically they were just another example of local forces winning a proxy war against a superior occupation force.
The only times in modern history where armed rebellion have overthrown an incumbent regime is via the proxy war route with direct and massive external material support. Often even that is only possible after the regime had suffered massive military losses from direct military action by superior hostile external military forces.
Look to the Middle East, despite massive foreign support and organisation, the Libyan opposition would have been crushed if not for western militaries directly intervening to act as their air force. Same with Iraq, where Saddam clung onto power despite loosing the Gulf War and being sanctioned and occasionally bombed by NATO for decades. Similar deal with Syria.
In all those countries, not only was gun ownership rates directly comparable to American ones, the civilian population had easy access to automatic weapons, RPGs and even heavier stuff while regime forces weren’t remotely as well equipped, trained, organised or motivated as US law enforcement.
The only question to any such armed uprising currently in the U.S. is how many easily replaceable ICE stormtroopers and regular police die. There will be zero threat to the US regime.