Coronavirus 2019-2020 thread (no unsubstantiated rumours!)

[j17wang]

Clover vaccines use Dynavax adjunct so it will probably not get a big order from China. But if the trial is successful, then it is possible that it would still be included in the national vaccine rollout. Clover is also position itself as an export focused vaccine. I think one issue for Clover is that it requires 3 doses like Zhifei subunit vaccines.

Clover's Phase III trials uses only 2 doses, 21 days apart. Clover will likely be export focused, but I would still expect demand to be at least close to a billion doses, if anything more to boost the CoronaVac/Sinopharm/Cansino shots which have been exported so far. Its going for approval with China, Europe, and WHO simultaneously.

I think the chinese second generation will be mostly booster shots, since I dont think many of us were expecting 50% of global vaccine production to have come from china even at Q3.

 

[KYli]

Clover's Phase III trials uses only 2 doses, 21 days apart. Clover will likely be export focused, but I would still expect demand to be at least close to a billion doses, if anything more to boost the CoronaVac/Sinopharm/Cansino shots which have been exported so far. Its going for approval with China, Europe, and WHO simultaneously.

I think the chinese second generation will be mostly booster shots, since I dont think many of us were expecting 50% of global vaccine production to have come from china even at Q3.

That's good. 2 shots would make it much more competitive. I think the issue is Clover took too long to get its Phase 3 of clincial trial started. It still has a good shot to sell a billion doses but it will not be that easy anymore as getting the trial results, obtaining approval, and ramping up production take time. Sinopharm and Sinovac vaccines would flood the world in the next 2-3 months. Pfizer, AstraZeneca, J&J, and Cansino would also be widely available soon after.

As for booster shots, Pfizer, Sinovac, and Sinopharm are further along the road for getting the approval to offer booster shots. By the time, Clover is ready. It still requires a few months of study before getting approval for offering a booster shot. Clover's advantages are that it is more prepared to gain approval from WHO and EU and at the time it already secured a contract with Covax if the trial results went well.

 

[KYli]

Interesting development, Pfizer wants to offer a booster shot and seek approval but both FDA and CDC issued statement that America doesn't need a booster shot yet.

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[j17wang]

That's good. 2 shots would make it much more competitive. I think the issue is Clover took too long to get its Phase 3 of clincial trial started. It still has a good shot to sell a billion doses but it will not be that easy anymore as getting the trial results, obtaining approval, and ramping up production take time. Sinopharm and Sinovac vaccines would flood the world in the next 2-3 months. Pfizer, AstraZeneca, J&J, and Cansino would also be widely available soon after.

As for booster shots, Pfizer, Sinovac, and Sinopharm are further along the road for getting the approval to offer booster shots. By the time, Clover is ready. It still requires a few months of study before getting approval for offering a booster shot. Clover's advantages are that it is more prepared to gain approval from WHO and EU and at the time it already secured a contract with Covax if the trial results went well.

Clover's trial was fully recruited on July 7. I expect they should hit primary endpoint within 60-90 days based on prior COVID-19 vaccines as everybody has now been jammed and the cases are running.

This time around, this should get faster approval as they have been running a process in western countries (Phase I was in Australia) and also under GAVI/CEPI/COVAX. I expect a quick approval like with the J&J vaccine. Even their peer-review results were published quite quickly after the trials ended. The good thing with sub-unit vaccines is they are easier to ramp up compared to inactivated.

 

[KYli]

Guess pragmatic prevailed against nationalism due to the spike of coronvavirus in Vietnam.

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[getready]

Not sure what went wrong in Indonesia. Let hope it could contain the Delta variant soon.

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Combination of lack of vaccination, confusing government policy, recent mass celebration of hari raya, delta variant, conspiracy theories online on Chinese vaccines, vaccines in general and covid, a poor health care system etc

Almost forgot a crucial one. Lack of testing. Severe lack of testing. From the beginning, the government did not do enough testing, under report cases and likely treated covid cases as flu.

 

[SteelBird]

Guess pragmatic prevailed against nationalism due to the spike of coronvavirus in Vietnam.

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Vietnam is on the brink of losing control of Covid-19. Looks like its directive 16 comes a bit too late for HCM city. Cambodia used to have very bad daily cases about 900+ for more than one week. Now Vietnam is worse with more than 1300+ a day and rising.

 

[KYli]

Turkey releases phase three trial result of Sinovac. 83.5% efficacy rate.

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After the UK, Spain has become another highly vaccinated country to see a surge.

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[solarz]

Vietnam is on the brink of losing control of Covid-19. Looks like its directive 16 comes a bit too late for HCM city. Cambodia used to have very bad daily cases about 900+ for more than one week. Now Vietnam is worse with more than 1300+ a day and rising.

As all those countries formerly considered to have handled covid well start to fall one by one, China remains steadfast as the one covid free bastion on the planet.

 

[Phead128]

I just saw this on CNN where they said Pfizer stopped tracking any breakthrough COVID-19 asymptomatic cases of people who took their vaccine meaning the media spins it as no such cases happening making it look its vaccine is highly effective.

Exactly, before the clinical trials finished, FDA and CDC said any vaccine >50% efficacy was excellent, given that the normal flu vaccine is only 30% efficacy. So somehow, China's efficacy is "poor" even though according to FDA/CDC definition, it was already excellent. Western media propaganda double standards.

Also, you know for a fact if China experimented with mRNA (unproven in vaccines), the West would shit over any minor side-effects like myocarditis, pericarditis, and smear it with "investigational, experimental, unproven" new technology. But when West does something completely new (With side-effects), it's all hush-hush.

Also, Pfizer stopped collecting data on asymptomatics is proof they are shifting the goal posts from asymptomatic infection to some other criteria like severe disease. That's really bullshit how they keep changing the goal posts while pretending they are super-duper effective while at same time bashing Chinese vaccines.