China's Biotech Industry

supercat

Colonel
Mast cell is responsible for triggering fast and strong allergic reactions. Chinese researches are trying to use this reaction to fight cancer.

Chinese scientists use allergy-like immune response for cancer therapy​

Instead of allowing mast cells to respond to allergens, the team reprogrammed them using IgE antibodies that recognize proteins found on tumor cells.

When these customized mast cells are injected into the bloodstream, they travel to tumors and unleash sudden bursts of inflammation upon encountering their specific cancer target.
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Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy​

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supercat

Colonel
Another one goes to China - SCMP headline and video summary below:

The YouTube video summary is no longer available. But the archived SCMP report is still there.

Cambridge University ex-vice-chancellor Nigel Slater joins China’s biotech revolution​

Veteran academic to collaborate with Chinese scientists to develop next-gen cancer therapies using vaccine tech for tumour immunotherapy
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Battery-integrated brain chip implant eliminates the risk of infection and enhances safety.
NeuroXess Achieves Milestone With China’s First Battery-Integrated Brain Chip Implant
...
Earlier generations of BCI products required battery modules to remain outside the skull and relied on external devices for power. NeuroXess’ product fully implants the core module containing the battery inside the body, integrating wireless power supply and wireless data transmission, allowing patients to dispense entirely with external equipment and fundamentally eliminating infection risks at the physical level, said Tao Hu, founder and chief scientist of NeuroXess.

The company has also placed the battery module subcutaneously in the chest and optimized the architecture of deep brain stimulation technology to move heat-generating components away from the brain, further enhancing system safety, Tao added.
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sunnymaxi

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GE Healthcare's only system-level MRI research and innovation center outside the United States has been established in Tianjin, China.​


Song Weiqun, Executive Vice President of GE Healthcare and President and CEO of Greater China, mentioned that this is GE Healthcare's "only system-level" R&D and innovation center outside the United States. This means that, going forward , all of GE Healthcare's system-level MRI R&D outside the United States, from core magnets, gradients, and coils to cutting-edge artificial intelligence technologies, will originate in Tianjin, China .

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supercat

Colonel
$1.4 billion deal for anti-hyperthyroidism immunotherapy that also treats thyroid eye disease.
China’s Changchun High-Tech Gains After Licensing Innovative Hyperthyroidism Drug to US Yarrow
GS-098 is a clinical-stage, first-in-class, humanized monoclonal antibody targeting the thyroid-stimulating hormone receptor for the treatment of Graves’ disease and thyroid eye disease. In August last year, it obtained regulatory approval for clinical trials for thyroid-associated orbitopathy in China and the United States. In October, it was approved for clinical trials for GD in China.
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Wrought

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New paper on pharmaceutical R&D shows that drug discovery has caught up to US levels, thanks to both Chinese growth and American complacency.

We analyzed more than 17,000 different drugs, biologics, and biologicals to identify the organizations responsible for the development of each. We then located these organizations’ headquarters and classified them as public or private-sector entities. We postulated that China’s contributions to drug discovery might be rising, perhaps ranking equal to long-standing pharmaceutical pioneers such as Switzerland or Japan. Reality was quite different.

When national contributions were compared on an annual basis, China had not merely surpassed the collective output of Europe and the rest of Asia, but gained parity with the United States. This outcome is all the more remarkable as the growth occurred almost entirely over the past decade. As an example, China’s output in terms of new drug discovery had increased from about 30 new medicines in 2013 to more than 400 a decade later. Output by American sources has remained comparatively flat since 2018, while China’s contributions nearly tripled in that same period.

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Randomuser

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AI drug designer Insilico Medicine aims to generate nearly $300M in Hong Kong IPO​


After reportedly flirting with going public for years, the artificial intelligence-powered drug developer Insilico Medicine has laid out plans to raise about $292 million through a listing on the Stock Exchange of Hong Kong.

The company plans to put up a total of more than 94 million shares—with about 10% offered in Hong Kong and the remainder placed internationally—priced at 24.05 per share in Hong Kong dollars, or about $3.09 U.S. apiece.

The IPO—scheduled to run through Dec. 23, with trading starting Dec. 30—will wrap up a year that saw Insilico raise $110 million through a March venture capital round and ink multiple R&D deals
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, including a recent pact with Eli Lilly potentially worth
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.

Insilico has long maintained an office in Hong Kong, and also counts outposts in Shanghai and Taipei, as well as Boston, New York, Montreal and Abu Dhabi. Since its 2014 founding, the former
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and
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has employed generative AI programs to help design molecules into potential drugs across a variety of diseases for its Big Pharma customers, as well as for its own internal research pipeline focused on fibrosis and longevity.

The company’s Pharma.AI platform spans target identification, small-molecule generation, and the prediction of clinical outcomes. Insilico also aims to bring more automation to laboratories, boosting their throughput in examining the countless compounds that AI can provide.

This past February, Insilico published benchmarking timelines from
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, which on average took about 13 months from the initial building of a large library of potential molecules through the whittling down to a chosen few for synthesis, testing and finally selection for clinical trials.

Prior to that, Insilico planted its flag in 2021 by identifying a new biological target linked to idiopathic pulmonary fibrosis, or IPF, designing a novel molecule to match and completing preclinical experiments,
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all within a span of 18 months. The company reported a price tag of about $2 million for this work, a dramatic cut from traditional drug discovery costs.

Now serving as the company’s lead internal candidate, rentosertib has cleared early safety studies in IPF and has shown improvements in lung function through a phase 2a placebo-controlled trial of 71 participants conducted in China. Formerly known as ISM001-055, the molecule represents a potentially first-in-class TNIK inhibitor. The study’s results were published
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.

In 2026, Insilico plans to examine rentosertib in a kidney fibrosis clinical trial, as well as in an inhalable formulation for the treatment of IPF.

In its
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(PDF) filed with the Hong Kong exchange, the company reported $85.8 million in revenue for the 2024 calendar year, with a net loss of $17.4 million. For the first six months of 2025, revenue and losses totaled $27.5 million and $18.9 million, respectively.


In terms of venture capital, Insilico has raised more than $500 million to date, with backers including Warburg Pincus, Qiming Venture Partners, WuXi AppTec, B Capital Group, Prosperity7, OrbiMed, Deerfield, Pavilion Capital, PIDC, CPE fund, Mirae Asset Capital, Lilly Asia Ventures, Eight Roads, Lake Bleu Capital, Baidu Ventures and Sinovation Ventures. Its $110 million series E round this year was led by the Hong Kong-based firm Value Partners.
 

sunnymaxi

Colonel
Registered Member
Decisively broke Germany and Japan duopoly.

The first domestically produced high-end surgical microscope in China has been put into service, and more than 70 hospitals have submitted their intention to purchase it.​


According to a report by Heilongjiang TV News today, the first high-end surgical microscope in China, independently developed by Harbin Haihong Jiyue, has officially been put into operation.

In the past, almost all "super microscopes" capable of performing high-precision surgeries were imported from abroad. Now, Haihong Jiyue's newly developed high-end surgical microscopes are being used in the operating rooms of many hospitals across the country.

The report mentioned that more than ten units have been sold in just one month since the product was launched. More than 70 hospitals nationwide have submitted their intention to purchase the product, and sales are expected to exceed 100 million yuan .

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